Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules
about
Function, regulation and pathological roles of the Gab/DOS docking proteinsThe molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesisThe role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptorsBood POZ containing gene type 2 is a human counterpart of yeast Btb3p and promotes the degradation of terminal deoxynucleotidyltransferaseGads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cellsSequence specificity of SHP-1 and SHP-2 Src homology 2 domains. Critical roles of residues beyond the pY+3 position.Receptor-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-76-ADAPThe nonphagocytic NADPH oxidase Duox1 mediates a positive feedback loop during T cell receptor signaling.Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent.Negative feedback of T cell activation through inhibitory adapters and costimulatory receptors.Protein Tyrosine Phosphatase SHP-2 (PTPN11) in Hematopoiesis and Leukemogenesis.Interaction of scaffolding adaptor protein Gab1 with tyrosine phosphatase SHP2 negatively regulates IGF-I-dependent myogenic differentiation via the ERK1/2 signaling pathwayAltered signaling triggered by ligation of the TCR/CD3 receptor in T lymphocytes from patients with systemic lupus erythematosus: the road from anergy to autoimmunity.Abnormal hematopoiesis in Gab2 mutant miceTransmembrane adaptor proteins: organizers of immunoreceptor signalling.Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosisRegulation of the mast cell response to the type 1 Fc epsilon receptor.G-CSF stimulates Jak2-dependent Gab2 phosphorylation leading to Erk1/2 activation and cell proliferation.Protein tyrosine phosphatase SHP2 regulates TGF-β1 production in airway epithelia and asthmatic airway remodeling in mice.Regulation of lymphocyte development and activation by the LAT family of adapter proteins.The LAT story: a tale of cooperativity, coordination, and choreography.The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation.Gab2 and Src co-operate in human mammary epithelial cells to promote growth factor independence and disruption of acinar morphogenesis.Activated STAT5 proteins induce activation of the PI 3-kinase/Akt and Ras/MAPK pathways via the Gab2 scaffolding adapter.Reduction of glycosphingolipid levels in lipid rafts affects the expression state and function of glycosylphosphatidylinositol-anchored proteins but does not impair signal transduction via the T cell receptor.Activated c-Met signals through PI3K with dramatic effects on cytoskeletal functions in small cell lung cancer.G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase.Growth factor receptor bound protein 2-associated binder 2, a scaffolding adaptor protein, negatively regulates host immunity against tuberculosis.Interaction of SAP-1, a transmembrane-type protein-tyrosine phosphatase, with the tyrosine kinase Lck. Roles in regulation of T cell function.LAT--an important raft-associated transmembrane adaptor protein. Delivered on 6 July 2009 at the 34th FEBS Congress in Prague, Czech Republic.CTLA-4, an Essential Immune-Checkpoint for T-Cell Activation.
P2860
Q21245511-ED1A01F5-25FE-4761-9803-8A7C768A7107Q24297505-91D5BD7A-EE24-45F0-BE33-CFBB55398D01Q28190019-7276885F-AB60-4D48-8F43-036F010FCB7AQ28277430-E15F2426-2111-4F94-8EB1-2C868B856220Q30164830-368E1FF9-CFBB-4A13-B6CB-CEB4B8CD1924Q33243531-91694110-761F-4298-A7F5-F200EB6121B0Q33893558-91B4022A-B127-4377-87C0-12D73D3BE71DQ34135661-2E5DB148-03A4-4903-A5C3-2845FE78E625Q34784704-F377E246-B1FD-41DE-B3BC-A50A3F8F7C7AQ35096700-7A10431F-9A08-466D-AB07-508F1D820A24Q35101627-93557C6F-AB78-4946-A3B2-B6CF2640CCA6Q35676632-E6EE80EE-16CF-450F-9D50-B2756D5E9DCBQ35809402-E7916FD6-075F-443D-9BC4-8E9C54C024F8Q35850643-10F07317-287F-4C1C-AF93-2E1EFF08A2F5Q35852278-7517A8B1-6FF1-4729-AF63-BC62DD3810F3Q36323583-345044F8-7F8F-46D9-A70D-8266A5BA618CQ36819928-B370AAB7-149A-46EC-9D8B-021B24B23735Q37459752-4F1AD6E9-F482-41FE-B631-FACDD2C039EBQ37616725-217BF4DE-E80F-4E95-A184-0A2E52AB32F9Q37631692-DEC44CFE-102C-4D0B-AF02-FBB49B79E75EQ37770817-E7D209CA-83FD-42C9-A1AC-8BBC614D6E39Q38059682-6CEAD0C7-30E1-4D39-A5D9-404EB848784AQ40052820-6806A4B8-0842-49F3-972F-FB43310E0F55Q40434680-E3823A0D-953D-49B1-B35D-8B9A98A7DE28Q40631889-0BD6797B-DCBE-4DE9-9B02-E3E5345CA920Q40667298-DE70A50B-E6DF-4153-ABF1-930D8B48C6D5Q42051165-55397D97-93B9-4D6E-BE96-08A1765EEFC5Q42220081-933AEEA6-888B-4AA4-B67A-D85C238EFEAEQ42444064-A54842D7-3FBC-479B-AEEE-98B1B5871FE2Q42875306-B3888B5E-DFF5-45A4-9956-1F73CADC38EEQ50125551-A93068B6-7910-4AE1-8D17-B049CA8775CE
P2860
Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules
description
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2001
@ast
im November 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 30 November 2001)
@en
vedecký článok (publikovaný 2001/11/30)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/11/30)
@nl
наукова стаття, опублікована в листопаді 2001
@uk
name
Docking protein Gab2 is phosph ...... itment of inhibitory molecules
@ast
Docking protein Gab2 is phosph ...... itment of inhibitory molecules
@en
Docking protein Gab2 is phosph ...... itment of inhibitory molecules
@nl
type
label
Docking protein Gab2 is phosph ...... itment of inhibitory molecules
@ast
Docking protein Gab2 is phosph ...... itment of inhibitory molecules
@en
Docking protein Gab2 is phosph ...... itment of inhibitory molecules
@nl
prefLabel
Docking protein Gab2 is phosph ...... itment of inhibitory molecules
@ast
Docking protein Gab2 is phosph ...... itment of inhibitory molecules
@en
Docking protein Gab2 is phosph ...... itment of inhibitory molecules
@nl
P2093
P2860
P356
P1476
Docking protein Gab2 is phosph ...... itment of inhibitory molecules
@en
P2093
S Yamasaki
P2860
P304
P356
10.1074/JBC.M105384200
P407
P577
2001-11-30T00:00:00Z