The mRNA cap structure stimulates rate of poly(A) removal and amplifies processivity of degradation
about
The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements.Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding proteinNuclear deadenylation/polyadenylation factors regulate 3' processing in response to DNA damage.Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylationSerum-deprivation stimulates cap-binding by PARN at the expense of eIF4E, consistent with the observed decrease in mRNA stabilityRecombinant messenger RNA technology and its application in cancer immunotherapy, transcript replacement therapies, pluripotent stem cell induction, and beyondThe RRM domain of poly(A)-specific ribonuclease has a noncanonical binding site for mRNA cap analog recognitionThe activity and selectivity of fission yeast Pop2p are affected by a high affinity for Zn2+ and Mn2+ in the active siteCoordination of divalent metal ions in the active site of poly(A)-specific ribonucleaseIdentification of the active site of poly(A)-specific ribonuclease by site-directed mutagenesis and Fe(2+)-mediated cleavageConcerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnoverMessenger RNA turnover in eukaryotes: pathways and enzymesAn integrated in silico approach to design specific inhibitors targeting human poly(a)-specific ribonucleaseMammalian PNLDC1 is a novel poly(A) specific exonuclease with discrete expression during early developmentStructural insight into poly(A) binding and catalytic mechanism of human PARN.mRNA deadenylation by PARN is essential for embryogenesis in higher plantsCharacterization of deadenylation in trypanosome extracts and its inhibition by poly(A)-binding protein Pab1pThe PARN deadenylase targets a discrete set of mRNAs for decay and regulates cell motility in mouse myoblastsIdentification of the major spliceosomal RNAs in Dictyostelium discoideum reveals developmentally regulated U2 variants and polyadenylated snRNAs.A fluorescence-based assay suitable for quantitative analysis of deadenylase enzyme activity.PolyA-specific ribonuclease (PARN-1) function in stage-specific mRNA turnover in Trypanosoma brucei.Poly(A)-specific ribonuclease deficiency impacts telomere biology and causes dyskeratosis congenita.A deadenylase assay by size-exclusion chromatography.Maturation of mammalian H/ACA box snoRNAs: PAPD5-dependent adenylation and PARN-dependent trimmingKiss your tail goodbye: the role of PARN, Nocturnin, and Angel deadenylases in mRNA biology.The control of mRNA decapping and P-body formation.Structural and functional insights into eukaryotic mRNA decapping.Deadenylation of cytoplasmic mRNA by the mammalian Ccr4-Not complex.Poly(A)-specific ribonuclease (PARN): an allosterically regulated, processive and mRNA cap-interacting deadenylase.MicroRNA-mediated gene silencing: are we close to a unifying model?Differential inhibition of mRNA degradation pathways by novel cap analogs.The 3' untranslated region of sindbis virus represses deadenylation of viral transcripts in mosquito and Mammalian cells.Analysis of mRNA deadenylation by multi-protein complexes.Recognition of adenosine residues by the active site of poly(A)-specific ribonuclease.Mouse CAF1 can function as a processive deadenylase/3'-5'-exonuclease in vitro but in yeast the deadenylase function of CAF1 is not required for mRNA poly(A) removal.Rapid ATP-dependent deadenylation of nanos mRNA in a cell-free system from Drosophila embryos.Bone marrow failure and developmental delay caused by mutations in poly(A)-specific ribonuclease (PARN).How miRs and mRNA deadenylases could post-transcriptionally regulate expression of tumor-promoting protein PLD.
P2860
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P2860
The mRNA cap structure stimulates rate of poly(A) removal and amplifies processivity of degradation
description
2001 nî lūn-bûn
@nan
2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
The mRNA cap structure stimula ...... es processivity of degradation
@ast
The mRNA cap structure stimula ...... es processivity of degradation
@en
The mRNA cap structure stimula ...... es processivity of degradation
@nl
type
label
The mRNA cap structure stimula ...... es processivity of degradation
@ast
The mRNA cap structure stimula ...... es processivity of degradation
@en
The mRNA cap structure stimula ...... es processivity of degradation
@nl
prefLabel
The mRNA cap structure stimula ...... es processivity of degradation
@ast
The mRNA cap structure stimula ...... es processivity of degradation
@en
The mRNA cap structure stimula ...... es processivity of degradation
@nl
P2093
P2860
P3181
P356
P1476
The mRNA cap structure stimula ...... es processivity of degradation
@en
P2093
P2860
P304
P3181
P356
10.1074/JBC.M102270200
P407
P577
2001-07-27T00:00:00Z