Divergent evolution of enzymatic function: mechanistically diverse superfamilies and functionally distinct suprafamilies
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Annotation error in public databases: misannotation of molecular function in enzyme superfamiliesA gold standard set of mechanistically diverse enzyme superfamilies.Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipidsCloning of nitroalkane oxidase from Fusarium oxysporum identifies a new member of the acyl-CoA dehydrogenase superfamily.Structural analysis of two enzymes catalysing reverse metabolic reactions implies common ancestryThe catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshotsUtilization of L-ascorbate by Escherichia coli K-12: assignments of functions to products of the yjf-sga and yia-sgb operonsKinetics and product analysis of the reaction catalysed by recombinant homoaconitase from Thermus thermophilusHigh-resolution analysis of Zn(2+) coordination in the alkaline phosphatase superfamily by EXAFS and x-ray crystallographyThe Enzyme Function Initiative.Activity-based proteomics of enzyme superfamilies: serine hydrolases as a case studyLateral gene transfer and parallel evolution in the history of glutathione biosynthesis genesTotal sequence decomposition distinguishes functional modules, "molegos" in apurinic/apyrimidinic endonucleasesCan sequence determine function?Gene fusions and gene duplications: relevance to genomic annotation and functional analysisProtein molecular function prediction by Bayesian phylogenomics.Why reinvent the wheel? Building new proteins based on ready-made partsEvolutionarily conserved linkage between enzyme fold, flexibility, and catalysisThe 2-A crystal structure of 6-oxo camphor hydrolase. New structural diversity in the crotonase superfamilyOrigin of the different pH activity profile in two homologous ketosteroid isomerasesCrystal structure of Mycobacterium tuberculosis MenB, a key enzyme in vitamin K2 biosynthesisThe structural determination of phosphosulfolactate synthase from Methanococcus jannaschii at 1.7-A resolution: an enolase that is not an enolaseStructure of the first representative of Pfam family PF04016 (DUF364) reveals enolase and Rossmann-like folds that combine to form a unique active site with a possible role in heavy-metal chelationHydrogen bonding of 7,8-dihydro-8-oxodeoxyguanosine with a charged residue in the little finger domain determines miscoding events in Sulfolobus solfataricus DNA polymerase Dpo4Structure ofStaphylococcus aureus1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB) in complex with acetoacetyl-CoAPromiscuous Partitioning of a Covalent Intermediate Common in the Pentein SuperfamilyEvolution of Enzymatic Activities in the Enolase Superfamily: l -Rhamnonate Dehydratase † ‡Comparative Enzymology in the Alkaline Phosphatase Superfamily to Determine the Catalytic Role of an Active-Site Metal IonStructural and Biophysical Characterization of BoxC from Burkholderia xenovorans LB400: A NOVEL RING-CLEAVING ENZYME IN THE CROTONASE SUPERFAMILYToxoflavin Lyase Requires a Novel 1-His-2-Carboxylate Facial Triad,Mechanism of the Intramolecular Claisen Condensation Reaction Catalyzed by MenB, a Crotonase Superfamily MemberOrganophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenasesElucidation of the Molecular Basis for Arabinoxylan-Debranching Activity of a Thermostable Family GH62 -L-Arabinofuranosidase from Streptomyces thermoviolaceusEnzymatic hydrolysis by transition-metal-dependent nucleophilic aromatic substitutionExploitation of latent allostery enables the evolution of new modes of MAP kinase regulationStructure of 6-oxo camphor hydrolase H122A mutant bound to its natural product, (2S,4S)-alpha-campholinic acid: mutant structure suggests an atypical mode of transition state binding for a crotonase homologEvolution of function in the "two dinucleotide binding domains" flavoproteinsEvolutionarily conserved substrate substructures for automated annotation of enzyme superfamiliesQuantitative comparison of catalytic mechanisms and overall reactions in convergently evolved enzymes: implications for classification of enzyme functionFLORA: a novel method to predict protein function from structure in diverse superfamilies
P2860
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P2860
Divergent evolution of enzymatic function: mechanistically diverse superfamilies and functionally distinct suprafamilies
description
2001 թուականին հրատարակուած գիտական յօդուած
@hyw
2001 թվականին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2001
@ast
im Januar 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 2001)
@en
vedecký článok (publikovaný 2001)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd in 2001)
@nl
наукова стаття, опублікована у 2001
@uk
مقالة علمية (نشرت عام 2001)
@ar
name
Divergent evolution of enzymat ...... ionally distinct suprafamilies
@ast
Divergent evolution of enzymat ...... ionally distinct suprafamilies
@en
Divergent evolution of enzymat ...... ionally distinct suprafamilies
@nl
type
label
Divergent evolution of enzymat ...... ionally distinct suprafamilies
@ast
Divergent evolution of enzymat ...... ionally distinct suprafamilies
@en
Divergent evolution of enzymat ...... ionally distinct suprafamilies
@nl
prefLabel
Divergent evolution of enzymat ...... ionally distinct suprafamilies
@ast
Divergent evolution of enzymat ...... ionally distinct suprafamilies
@en
Divergent evolution of enzymat ...... ionally distinct suprafamilies
@nl
P3181
P1476
Divergent evolution of enzymat ...... ionally distinct suprafamilies
@en
P2093
P C Babbitt
P304
P3181
P356
10.1146/ANNUREV.BIOCHEM.70.1.209
P407
P577
2001-01-01T00:00:00Z