Molecular characterization of hCTR1, the human copper uptake protein
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The N-terminus of the human copper transporter 1 (hCTR1) is localized extracellularly, and interacts with itselfProjection structure of the human copper transporter CTR1 at 6-A resolution reveals a compact trimer with a novel channel-like architecture.Human copper transporter 2 is localized in late endosomes and lysosomes and facilitates cellular copper uptakePollutant particles produce vasoconstriction and enhance MAPK signaling via angiotensin type I receptorHow Mammalian Cells Acquire Copper: An Essential but Potentially Toxic MetalSLC31 (CTR) family of copper transporters in health and diseaseCharacterization of mouse embryonic cells deficient in the ctr1 high affinity copper transporter. Identification of a Ctr1-independent copper transport systemCopper-stimulated endocytosis and degradation of the human copper transporter, hCtr1Identification of methionine-rich clusters that regulate copper-stimulated endocytosis of the human Ctr1 copper transporterStructural biology of copper traffickingCisplatin stabilizes a multimeric complex of the human Ctr1 copper transporter: requirement for the extracellular methionine-rich clustersIdentification of a receptor for an extinct virusAn all-atom model of the structure of human copper transporter 1.The role of the N-terminus of mammalian copper transporter 1 in the cellular accumulation of cisplatinHow copper traverses cellular membranes through the mammalian copper transporter 1, Ctr1.The role of Ctr1 and Ctr2 in mammalian copper homeostasis and platinum-based chemotherapy.Regulation of Cisplatin cytotoxicity by cu influx transporters.Acquisition of dietary copper: a role for anion transporters in intestinal apical copper uptake.The transport mechanism of bacterial Cu+-ATPases: distinct efflux rates adapted to different function.Upregulated copper transporters in hypoxia-induced pulmonary hypertension.Molecular modulation of the copper and cisplatin transport function of CTR1 and its interaction with IRS-4.Copper transporters and the cellular pharmacology of the platinum-containing cancer drugs.Model peptides provide new insights into the role of histidine residues as potential ligands in human cellular copper acquisition via Ctr1.Metal transport across biomembranes: emerging models for a distinct chemistry.Expression in Sf9 insect cells, purification and functional reconstitution of the human proton-coupled folate transporter (PCFT, SLC46A1).NMR and mutagenesis of human copper transporter 1 (hCtr1) show that Cys-189 is required for correct folding and dimerization.The copper transporter (Ctr) family of Cu+ uptake systems.Hyperthermic potentiation of cisplatin by magnetic nanoparticle heaters is correlated with an increase in cell membrane fluidityCellular glutathione plays a key role in copper uptake mediated by human copper transporter 1.A re-evaluation of the role of hCTR1, the human high-affinity copper transporter, in platinum-drug entry into human cellsRate and regulation of copper transport by human copper transporter 1 (hCTR1)Three-dimensional structure of the human copper transporter hCTR1.Copper transport protein (Ctr1) levels in mice are tissue specific and dependent on copper status.Variable response of selected cuproproteins in rat choroid plexus and cerebellum following perinatal copper deficiencyCopper transport in mammalian cells: special care for a metal with special needs.Copper-dependent recycling of hCTR1, the human high affinity copper transporter.Human copper transporter 1 lacking O-linked glycosylation is proteolytically cleaved in a Rab9-positive endosomal compartment.Characterization of a monoclonal antibody capable of reliably quantifying expression of human Copper Transporter 1 (hCTR1)Human copper transporters: mechanism, role in human diseases and therapeutic potential.Handling of Copper and Copper Oxide Nanoparticles by Astrocytes.
P2860
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P2860
Molecular characterization of hCTR1, the human copper uptake protein
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2002 nî lūn-bûn
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2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Molecular characterization of hCTR1, the human copper uptake protein
@ast
Molecular characterization of hCTR1, the human copper uptake protein
@en
Molecular characterization of hCTR1, the human copper uptake protein
@nl
type
label
Molecular characterization of hCTR1, the human copper uptake protein
@ast
Molecular characterization of hCTR1, the human copper uptake protein
@en
Molecular characterization of hCTR1, the human copper uptake protein
@nl
prefLabel
Molecular characterization of hCTR1, the human copper uptake protein
@ast
Molecular characterization of hCTR1, the human copper uptake protein
@en
Molecular characterization of hCTR1, the human copper uptake protein
@nl
P2860
P356
P1476
Molecular characterization of hCTR1, the human copper uptake protein
@en
P2093
Jack H Kaplan
John F Eisses
P2860
P304
P356
10.1074/JBC.M203652200
P407
P577
2002-08-09T00:00:00Z