Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
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Functional differences in visceral and subcutaneous fat pads originate from differences in the adipose stem cellMicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic outputBypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locusMyeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activityIdentification of a polymorphism in the RING finger of human Bmi-1 that causes its degradation by the ubiquitin-proteasome systemRecognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complexPTEN inhibits BMI1 function independently of its phosphatase activityMAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cellsSeveral distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locusStructure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1bUbiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressorMicroarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancerStable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligaseMammary stem cells, self-renewal pathways, and carcinogenesisBmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways.Geminin regulates neuronal differentiation by antagonizing Brg1 activityLong-term renewal of hair follicles from clonogenic multipotent stem cellsImprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignanciesGrowth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASGCancerous stem cells can arise from pediatric brain tumorsEZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repairBmi1, stem cells, and senescence regulationSingle-cell dissection of transcriptional heterogeneity in human colon tumorsBmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferationThe polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activityIdentification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cellsHmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf ExpressionBmi-1 is a target gene for SALL4 in hematopoietic and leukemic cellsContribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesisCD34+ hematopoietic stem-progenitor cell microRNA expression and function: a circuit diagram of differentiation controlThe Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cellsMel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteinsMammary epithelial cell transformation: insights from cell culture and mouse models.Differential expression of novel potential regulators in hematopoietic stem cells.p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells.Absence of mutations in the coding sequence of the potential tumor suppressor 3pK in metastatic melanomaEpigenetic Regulation of Hematopoietic Stem CellsEpigenetic perturbations in aging stem cellsBMI1: A Biomarker of Hematologic Malignancies
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P2860
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
@ast
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
@en
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
@nl
type
label
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
@ast
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
@en
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
@nl
prefLabel
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
@ast
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
@en
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
@nl
P2093
P2860
P3181
P356
P1433
P1476
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
@en
P2093
Dalong Qian
In-kyung Park
Irving L Weissman
Michael F Clarke
Michael Pihalja
P2860
P2888
P3181
P356
10.1038/NATURE01587
P407
P577
2003-05-15T00:00:00Z
P5875
P6179
1024497082