PI3Kgamma inhibition: towards an 'aspirin of the 21st century'?
about
NADPH oxidases in heart failure: poachers or gamekeepers?Phosphoinositides: tiny lipids with giant impact on cell regulationRegulation of platelet plug formation by phosphoinositide metabolismClass I PI3K inhibitor ZSTK474 mediates a shift in microglial/macrophage phenotype and inhibits inflammatory response in mice with cerebral ischemia/reperfusion injury.PI3Kγ Is Critical for Dendritic Cell-Mediated CD8+ T Cell Priming and Viral Clearance during Influenza Virus InfectionMultiple phosphatidylinositol 3-kinases regulate vaccinia virus morphogenesisGenetic enhancement of behavioral itch responses in mice lacking phosphoinositide 3-kinase-γ (PI3Kγ)A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiationC5a mediates peripheral blood neutrophil dysfunction in critically ill patientsInhibition of G-protein βγ signaling enhances T cell receptor-stimulated interleukin 2 transcription in CD4+ T helper cellsA role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability.Insulin granule recruitment and exocytosis is dependent on p110gamma in insulinoma and human beta-cellsRas is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gammaPhosphoinositide 3-kinase gamma required for lipopolysaccharide-induced transepithelial neutrophil trafficking in the lung.The mechanisms of up-regulation of dendritic cell activity by oxidative stressPI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway.Maps of open chromatin guide the functional follow-up of genome-wide association signals: application to hematological traits.Differential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: potential roles in acute inflammatory painElevated RalA activity in the hippocampus of PI3Kγ knock-out mice lacking NMDAR-dependent long-term depressionPhosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophagesPI3K: from the bench to the clinic and back.Developing a gene expression model for predicting ventilator-associated pneumonia in trauma patients: a pilot studyRab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling.Effects of PI3Kγ overexpression in the hippocampus on synaptic plasticity and spatial learning.Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance.PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis.Critical role for phosphoinositide 3-kinase gamma in parasite invasion and disease progression of cutaneous leishmaniasis.Biological evaluation and docking studies of recently identified inhibitors of phosphoinositide-3-kinases.PI3Ks in lymphocyte signaling and developmentPhosphoinositide 3-Kinase Gamma Contributes to Neuroinflammation in a Rat Model of Surgical Brain Injury.The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetes.PI3Kγ Deficient NOD-Mice Are Protected from Diabetes by Restoring the Balance of Regulatory to Effector-T-Cells.The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic DiseasesPI3K signalling in B- and T-lymphocytes: new developments and therapeutic advancesEndothelial p110γPI3K Mediates Endothelial Regeneration and Vascular Repair After Inflammatory Vascular InjuryPhosphoinositide 3-kinase signalling in lung disease: leucocytes and beyond.Anti-tumor efficacy of BEZ235 is complemented by its anti-angiogenic effects via downregulation of PI3K-mTOR-HIF1alpha signaling in HER2-defined breast cancers.Role of phosphoinositide 3-kinase signaling in autoimmunity.Lymphocyte cell motility: the twisting, turning tale of phosphoinositide 3-kinase.High-throughput kinase profiling as a platform for drug discovery.
P2860
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P2860
PI3Kgamma inhibition: towards an 'aspirin of the 21st century'?
description
2006 nî lūn-bûn
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2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
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2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
PI3Kgamma inhibition: towards an 'aspirin of the 21st century'?
@ast
PI3Kgamma inhibition: towards an 'aspirin of the 21st century'?
@en
PI3Kgamma inhibition: towards an 'aspirin of the 21st century'?
@nl
type
label
PI3Kgamma inhibition: towards an 'aspirin of the 21st century'?
@ast
PI3Kgamma inhibition: towards an 'aspirin of the 21st century'?
@en
PI3Kgamma inhibition: towards an 'aspirin of the 21st century'?
@nl
prefLabel
PI3Kgamma inhibition: towards an 'aspirin of the 21st century'?
@ast
PI3Kgamma inhibition: towards an 'aspirin of the 21st century'?
@en
PI3Kgamma inhibition: towards an 'aspirin of the 21st century'?
@nl
P2093
P3181
P356
P1476
PI3Kgamma inhibition: towards an 'aspirin of the 21st century'?
@en
P2093
Christian Rommel
Matthias K Schwarz
Thomas Rückle
P2888
P304
P3181
P356
10.1038/NRD2145
P407
P577
2006-11-01T00:00:00Z