The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4
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Genetic predictors of interindividual variability in hepatic CYP3A4 expressionRoles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor.Biology of PXR: role in drug-hormone interactionsDual-color fluorescence imaging to monitor CYP3A4 and CYP3A7 expression in human hepatic carcinoma HepG2 and HepaRG cellsPregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator InteractionsInduction of cytochrome P450 1A by cow milk-based formula: a comparative study between human milk and formulaIn vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping.Signalling cross-talk between hepatocyte nuclear factor 4alpha and growth-hormone-activated STAT5bPhenobarbital regulates nuclear expression of HNF-4alpha in mouse and rat hepatocytes independent of CAR and PXRThe nuclear receptor hepatocyte nuclear factor 4alpha acts as a morphogen to induce the formation of microvilliGenetic variability in CYP3A5 and its possible consequences.Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1.The transcriptional regulation of the human CYP2C genesA switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease.Evaluation of the HC-04 cell line as an in vitro model for mechanistic assessment of changes in hepatic cytochrome P450 3A during adenovirus infection.Hepatocyte nuclear factor 4{alpha} regulates rifampicin-mediated induction of CYP2C genes in primary cultures of human hepatocytesDiscovering networks of perturbed biological processes in hepatocyte culturesThe far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alphaSystematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver.Hepatitis C virus entry is impaired by claudin-1 downregulation in diacylglycerol acyltransferase-1-deficient cells.Camptothecin attenuates cytochrome P450 3A4 induction by blocking the activation of human pregnane X receptorEvaluation of computational docking to identify pregnane X receptor agonists in the ToxCast database.HNF4α--role in drug metabolism and potential drug target?Pregnane X receptor and drug-induced liver injury.The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis.Metabolism and action of proteasome inhibitors in primary human hepatocytesMed25 is required for RNA polymerase II recruitment to specific promoters, thus regulating xenobiotic and lipid metabolism in human liver.NCOA6 differentially regulates the expression of the CYP2C9 and CYP3A4 genesRifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.Drug-activated nuclear receptors CAR and PXR.Application of Caco-2 cell line in herb-drug interaction studies: current approaches and challengesExpression of xenobiotic metabolizing enzymes in different lung compartments of smokers and nonsmokersCINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor.Intrinsic sexually dimorphic expression of the principal human CYP3A4 correlated with suboptimal activation of GH/glucocorticoid-dependent transcriptional pathways in men.A case of metastatic renal cell carcinoma and bile duct carcinoma treated with a combination of sunitinib and gemcitabine.Small-molecule modulators of the constitutive androstane receptor.Transactivation of a DR-1 PPRE by a human constitutive androstane receptor variant expressed from internal protein translation start sites.Cytochrome P450: what have we learned and what are the future issues?Nuclear receptor variants in liver disease.Transcriptional Regulation of CYP2B6 Expression by Hepatocyte Nuclear Factor 3β in Human Liver Cells.
P2860
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P2860
The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4
description
2003 nî lūn-bûn
@nan
2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The orphan nuclear receptor HN ...... xenobiotic induction of CYP3A4
@ast
The orphan nuclear receptor HN ...... xenobiotic induction of CYP3A4
@en
The orphan nuclear receptor HN ...... xenobiotic induction of CYP3A4
@nl
type
label
The orphan nuclear receptor HN ...... xenobiotic induction of CYP3A4
@ast
The orphan nuclear receptor HN ...... xenobiotic induction of CYP3A4
@en
The orphan nuclear receptor HN ...... xenobiotic induction of CYP3A4
@nl
prefLabel
The orphan nuclear receptor HN ...... xenobiotic induction of CYP3A4
@ast
The orphan nuclear receptor HN ...... xenobiotic induction of CYP3A4
@en
The orphan nuclear receptor HN ...... xenobiotic induction of CYP3A4
@nl
P2093
P3181
P356
P1433
P1476
The orphan nuclear receptor HN ...... xenobiotic induction of CYP3A4
@en
P2093
Brenda F Leake
Cynthia Brimer Cline
Erin G Schuetz
Fereshteh Parviz
Frank J Gonzalez
Lu-Bin Lan
Richard B Kim
Rommel G Tirona
Vishal Lamba
Yusuke Inoue
P2888
P304
P3181
P356
10.1038/NM815
P407
P577
2003-01-06T00:00:00Z