The human involucrin gene contains spatially distinct regulatory elements that regulate expression during early versus late epidermal differentiation
about
sameAs
A distal region of the human TGM1 promoter is required for expression in transgenic mice and cultured keratinocytesLoricrin expression in cultured human keratinocytes is controlled by a complex interplay between transcription factors of the Sp1, CREB, AP1, and AP2 familiesApigenin inhibition of involucrin gene expression is associated with a specific reduction in phosphorylation of protein kinase Cdelta Tyr311Suppression of AP1 transcription factor function in keratinocyte suppresses differentiationDifferentiation-associated genes regulated by c-Jun and decreased in the progression of esophageal squamous cell carcinoma.Suppressing AP1 factor signaling in the suprabasal epidermis produces a keratoderma phenotype.Protein kinase C (PKC) delta suppresses keratinocyte proliferation by increasing p21(Cip1) level by a KLF4 transcription factor-dependent mechanism.12-O-Tetradecanoylphorbol-13-Acetate Induces Up-Regulated Transcription of Variant 1 but Not Variant 2 of VIL2 in Esophageal Squamous Cell Carcinoma Cells via ERK1/2/AP-1/Sp1 SignalingMethylosome Protein 50 and PKCδ/p38δ Protein Signaling Control Keratinocyte Proliferation via Opposing Effects on p21Cip1 Gene ExpressionEvidence that involucrin, a marker for differentiation, is oxygen regulated in human squamous cell carcinomasKeratinocyte proliferation, differentiation, and apoptosis--differential mechanisms of regulation by curcumin, EGCG and apigenin.Protein kinase C δ increases Kruppel-like factor 4 protein, which drives involucrin gene transcription in differentiating keratinocytes.Synergistic activation of human involucrin gene expression by Fra-1 and p300--evidence for the presence of a multiprotein complex.Loss of epidermal AP1 transcription factor function reduces filaggrin level, alters chemokine expression and produces an ichthyosis-related phenotype.AP1 factor inactivation in the suprabasal epidermis causes increased epidermal hyperproliferation and hyperkeratosis but reduced carcinogen-dependent tumor formationMEP50/PRMT5 Reduces Gene Expression by Histone Arginine Methylation and this Is Reversed by PKCδ/p38δ Signaling.Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis.Curcumin suppresses AP1 transcription factor-dependent differentiation and activates apoptosis in human epidermal keratinocytes.
P2860
Q24802668-B1B4521F-D1C3-413E-AF3E-B46C8E8CD795Q28219317-E8307756-459D-4CB1-8D68-FFEC61149AA7Q28264259-0F6160B9-BDE0-4EA4-8B7B-8FD0205951D4Q28729714-10D8B26F-6994-45B9-8361-F941E3047AECQ33567934-7E6A9BA6-549A-448F-B938-9C7097456517Q34717389-57992050-334D-425B-8503-3BA370CEF687Q35309397-D6CE0717-4981-4D0B-914F-A47F40A8DAABQ35615528-7C07E404-AC3F-4CFB-9960-FC6AD98F1426Q35861025-378788DD-E527-4FB3-9025-89BE96D4B7D5Q36694582-A9834572-8E14-45F9-A803-A98425211BD1Q36817539-0F03E693-B898-4312-BADE-A3583857B797Q36929105-797B44B1-03B6-4DC8-A177-9A9E0FFF50D6Q37157320-B8451C63-2F5D-4BE1-A8F3-B5A3F5732A6EQ41084067-88FC3205-7195-4C2D-B2CA-B2D4A0ED219FQ42201057-518E364B-B13D-4F6F-A923-3A8AE1AF644EQ42736264-B8D5C3DE-929D-43AF-B012-8D7C7F843B6DQ42935186-56BF6AD7-41B8-472F-B830-54510D7B2494Q53584526-321FCD18-CD2D-43B3-A427-31CDF8D825D0
P2860
The human involucrin gene contains spatially distinct regulatory elements that regulate expression during early versus late epidermal differentiation
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The human involucrin gene cont ...... late epidermal differentiation
@ast
The human involucrin gene cont ...... late epidermal differentiation
@en
The human involucrin gene cont ...... late epidermal differentiation
@nl
type
label
The human involucrin gene cont ...... late epidermal differentiation
@ast
The human involucrin gene cont ...... late epidermal differentiation
@en
The human involucrin gene cont ...... late epidermal differentiation
@nl
prefLabel
The human involucrin gene cont ...... late epidermal differentiation
@ast
The human involucrin gene cont ...... late epidermal differentiation
@en
The human involucrin gene cont ...... late epidermal differentiation
@nl
P2093
P2860
P356
P1433
P1476
The human involucrin gene cont ...... late epidermal differentiation
@en
P2093
Eric B Banks
Frederic Bone
James F Crish
Richard L Eckert
P2860
P2888
P304
P356
10.1038/SJ.ONC.1205038
P407
P577
2002-01-24T00:00:00Z
P5875
P6179
1031403427