Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation
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Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3' regulatory region.TLR9 Ligand (CpG Oligodeoxynucleotide) Induces CLL B-Cells to Differentiate into CD20(+) Antibody-Secreting Cells.Richter's and prolymphocytic transformation of chronic lymphocytic leukemia are associated with high mRNA expression of activation-induced cytidine deaminase and aberrant somatic hypermutation.What role for AID: mutator, or assembler of the immunoglobulin mutasome?Genomic uracil homeostasis during normal B cell maturation and loss of this balance during B cell cancer development.Splice variants of activation induced deaminase (AID) do not affect the efficiency of class switch recombination in murine CH12F3 cells.Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation.Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice.Novel molecular diagnostic and therapeutic targets in chronic lymphocytic leukaemia.TLR-9 and IL-15 Synergy Promotes the In Vitro Clonal Expansion of Chronic Lymphocytic Leukemia B Cells.HSP90 inhibitors decrease AID levels and activity in mice and in human cells.Stromal endothelial cells establish a bidirectional crosstalk with chronic lymphocytic leukemia cells through the TNF-related factors BAFF, APRIL, and CD40L.The Number of Overlapping AID Hotspots in Germline IGHV Genes Is Inversely Correlated with Mutation Frequency in Chronic Lymphocytic Leukemia.Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolutionDNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination.IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functionsNew molecular markers in resistant B-CLL.Chronic lymphocytic leukemia cells diversify and differentiate in vivo via a nonclassical Th1-dependent, Bcl-6-deficient processAlternative splicing regulates activation-induced cytidine deaminase (AID): implications for suppression of AID mutagenic activity in normal and malignant B cells.Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia.Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance."Role of the B-cell receptor and the microenvironment in chronic lymphocytic leukemia''.Chronic lymphocytic leukaemia: could immunological tolerance mechanisms be the origin of lymphoid neoplasms?Dissecting chronic lymphocytic leukemia microenvironment signals in patients with unmutated disease: microRNA-22 regulates phosphatase and tensin homolog/AKT/FOXO1 pathway in proliferative leukemic cells.Targeting activation-induced cytidine deaminase overcomes tumor evasion of immunotherapy by CTLs.Nuclear Exclusion of the HIV-1 host defense factor APOBEC3G requires a novel cytoplasmic retention signal and is not dependent on RNA binding.Activation-induced cytidine deaminase fails to induce a mutator phenotype in the human pre-B cell line Nalm-6.Activation-induced cytidine deaminase expression in follicular lymphoma: association between AID expression and ongoing mutation in FL.Expression of activation-induced cytidine deaminase is associated with a poor prognosis of diffuse large B cell lymphoma patients treated with CHOP-based chemotherapy.Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemiaAPOBEC-1 and AID are nucleo-cytoplasmic trafficking proteins but APOBEC3G cannot trafficAID protein expression in chronic lymphocytic leukemia/small lymphocytic lymphoma is associated with poor prognosis and complex genetic alterations.High expression of activation-induced cytidine deaminase (AID) mRNA is associated with unmutated IGVH gene status and unfavourable cytogenetic aberrations in patients with chronic lymphocytic leukaemia.RBM5 promotes exon 4 skipping of AID pre-mRNA by competing with the binding of U2AF65 to the polypyrimidine tract.Analysis of IgV gene mutations in B cell chronic lymphocytic leukaemia according to antigen-driven selection identifies subgroups with different prognosis and usage of the canonical somatic hypermutation machinery.Chronic Lymphocytic Leukemia B-Cell Normal Cellular Counterpart: Clues From a Functional Perspective.Activation-induced cytidine deaminase mRNA levels in chronic lymphocytic leukemia.Immunoglobulin heavy chain V-D-J gene rearrangement and mutational status in Uruguayan patients with chronic lymphocytic leukemiaHigh expression of lipoprotein lipase in poor risk B-cell chronic lymphocytic leukemia
P2860
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P2860
Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Chronic lymphocytic leukemia B ...... tion and somatic hypermutation
@ast
Chronic lymphocytic leukemia B ...... tion and somatic hypermutation
@en
Chronic lymphocytic leukemia B ...... tion and somatic hypermutation
@nl
type
label
Chronic lymphocytic leukemia B ...... tion and somatic hypermutation
@ast
Chronic lymphocytic leukemia B ...... tion and somatic hypermutation
@en
Chronic lymphocytic leukemia B ...... tion and somatic hypermutation
@nl
prefLabel
Chronic lymphocytic leukemia B ...... tion and somatic hypermutation
@ast
Chronic lymphocytic leukemia B ...... tion and somatic hypermutation
@en
Chronic lymphocytic leukemia B ...... tion and somatic hypermutation
@nl
P2093
P1433
P1476
Chronic lymphocytic leukemia B ...... tion and somatic hypermutation
@en
P2093
Beatrice Payelle-Brogard
Christian Magnac
Françoise Vuillier
Guillaume Dighiero
Gérard Dumas
Otto Pritsch
Yuri Vasconcelos
P304
P356
10.1182/BLOOD-2002-10-3175
P407
P577
2003-01-09T00:00:00Z