about
Potent and specific inhibition of glycosidases by small artificial binding proteins (affitins)Crystal structure of an enzymatically inactive trans-sialidase-like lectin from Trypanosoma cruzi: the carbohydrate binding mechanism involves residual sialidase activityStructure of a human IgA1 Fab fragment at 1.55 Å resolution: potential effect of the constant domains on antigen-affinity modulationChronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutationHuman endogenous retrovirus np9 gene is over expressed in chronic lymphocytic leukemia patients.HSP90 inhibitors decrease AID levels and activity in mice and in human cells.Effective antitumor therapy based on a novel antibody-drug conjugate targeting the Tn carbohydrate antigenGeneration of a vector suite for protein solubility screening.Tuning different expression parameters to achieve soluble recombinant proteins in E. coli: advantages of high-throughput screening."Role of the B-cell receptor and the microenvironment in chronic lymphocytic leukemia''.Overcoming the solubility problem in E. coli: available approaches for recombinant protein production.GALNT11 as a new molecular marker in chronic lymphocytic leukemia.S100-A9 protein in exosomes from chronic lymphocytic leukemia cells promotes NF-κB activity during disease progression.Dissecting chronic lymphocytic leukemia microenvironment signals in patients with unmutated disease: microRNA-22 regulates phosphatase and tensin homolog/AKT/FOXO1 pathway in proliferative leukemic cells.Surface localization of high-mobility group nucleosome-binding protein 2 on leukemic B cells from patients with chronic lymphocytic leukemia is related to secondary autoimmune hemolytic anemia.Antibody-dependent cell cytotoxicity synapses form in mice during tumor-specific antibody immunotherapy.Production and functional characterization of two mouse/human chimeric antibodies with specificity for the tumor-associated Tn-antigen.Sphingosine kinase 1 participates in the activation, proliferation and survival of chronic lymphocytic leukemia cells.Different isoforms of BSAP regulate expression of AID in normal and chronic lymphocytic leukemia B cells.Binet's staging system and VH genes are independent but complementary prognostic indicators in chronic lymphocytic leukemia.Lipoprotein lipase expression in unmutated CLL patients is the consequence of a demethylation process induced by the microenvironment.Structural and kinetic analysis of two covalent sialosyl-enzyme intermediates on Trypanosoma rangeli sialidase.Molecular cloning of a monoclonal anti-tumor antibody specific for the Tn antigen and expression of an active single-chain Fv fragment.Lipoprotein Lipase Expression in Chronic Lymphocytic Leukemia: New Insights into Leukemic Progression.Methylation status regulates lipoprotein lipase expression in chronic lymphocytic leukemia.The expression of sphingosine-1 phosphate receptor-1 in chronic lymphocytic leukemia cells is impaired by tumor microenvironmental signals and enhanced by piceatannol and R406.Do CLL B cells correspond to naive or memory B-lymphocytes? Evidence for an active Ig switch unrelated to phenotype expression and Ig mutational pattern in B-CLL cells.Noninfectious complications in patients with pediatric-onset common variable immunodeficiency correlated with defects in somatic hypermutation but not in class-switch recombination.Activation of the PI3K/AKT pathway by microRNA-22 results in CLL B-cell proliferation.Gene expression profiling of chronic lymphocytic leukemia can discriminate cases with stable disease and mutated Ig genes from those with progressive disease and unmutated Ig genes.Multi-Compartment and Multi-Host Vector Suite for Recombinant Protein Expression and Purification.The LPL/ADAM29 expression ratio is a novel prognosis indicator in chronic lymphocytic leukemiaLPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLLCCR4 expression in a case of cutaneous Richter’s transformation of chronic lymphocytic leukemia (CLL) to diffuse large B-cell lymphoma (DLBCL) and in CLL patients with no skin manifestationsImmunoglobulin heavy chain V-D-J gene rearrangement and mutational status in Uruguayan patients with chronic lymphocytic leukemiaChronic Lymphocytic Leukemia Cells Bind and Present the Erythrocyte Protein Band 3: Possible Role as Initiators of Autoimmune Hemolytic AnemiaLower levels of surface B-cell-receptor expression in chronic lymphocytic leukemia are associated with glycosylation and folding defects of the and CD79a chainsAutoanticorps, tolérance et auto-immunitéIdiotype-pulsed dendritic cells are able to induce antitumoral cytotoxic CD8 cells in chronic lymphocytic leukaemiaRetention and defective assembly of the B-cell receptor in the endoplasmic reticulum of chronic lymphocytic leukaemia B cells cannot be reverted upon CD40 ligand stimulation
P50
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P50
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hulumtues
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հետազոտող
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Pablo Oppezzo
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Pablo Oppezzo
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Pablo Oppezzo
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Pablo Oppezzo
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Pablo Oppezzo
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Pablo Oppezzo
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Pablo Oppezzo
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Pablo Oppezzo
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Pablo Oppezzo
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Pablo Oppezzo
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Pablo Oppezzo
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Pablo Oppezzo
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Pablo Oppezzo
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Pablo Oppezzo
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Pablo Oppezzo
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P106
P21
P31
P496
0000-0003-4194-246X