Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53 - Wikidata - awgldk - TriplyDB

Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53

Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53

http://www.wikidata.org/entity/Q28204132

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The transcription factor p53: not a repressor, solely an activator Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5 An approach to genomewide screens of expressed small interfering RNAs in mammalian cells.Chromatin immunoprecipitation-based screen to identify functional genomic binding sites for sequence-specific transactivators.NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation.Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor.Differential up-regulation of MAP kinase phosphatases MKP3/DUSP6 and DUSP5 by Ets2 and c-Jun converge in the control of the growth arrest versus proliferation response of MCF-7 breast cancer cells to phorbol ester.Whole genome expression profiling shows that BRG1 transcriptionally regulates UV inducible genes and other novel targets in human cells Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression Unique gene expression profile associated with an early-onset multiple endocrine neoplasia (MEN1)-associated pituitary adenoma Down-regulation of dual-specificity phosphatase 5 predicts poor prognosis of patients with prostate cancer Identification of inhibitors that target dual-specificity phosphatase 5 provide new insights into the binding requirements for the two phosphate pockets Dual Specificity Phosphatase 5, a Specific Negative Regulator of ERK Signaling, Is Induced by Serum Response Factor and Elk-1 Transcription Factor DUSPs, to MAP kinases and beyond.Dual Specificity Phosphatase 5 Is Essential for T Cell Survival Highly synergistic effect of sequential treatment with epigenetic and anticancer drugs to overcome drug resistance in breast cancer cells is mediated via activation of p21 gene expression leading to G2/M cycle arrest.A new p53 target gene, RKIP, is essential for DNA damage-induced cellular senescence and suppression of ERK activation.Lentivirus-mediated PLCγ1 gene short-hairpin RNA suppresses tumor growth and metastasis of human gastric adenocarcinoma.High expression of Zinc-finger protein X-linked promotes tumor growth and predicts a poor outcome for stage II/III colorectal cancer patients Identification of RASAL1 as a major tumor suppressor gene in thyroid cancer p53 predominantly regulates IL-6 production and suppresses synovial inflammation in fibroblast-like synoviocytes and adjuvant-induced arthritis Effects of Abies sibirica terpenes on cancer- and aging-associated pathways in human cells.Targeting DUSPs in glioblastomas - wielding a double-edged sword?Identification of novel vascular endothelial-specific genes by the microarray analysis of the zebrafish cloche mutants.DUSP6 is a novel transcriptional target of p53 and regulates p53-mediated apoptosis by modulating expression levels of Bcl-2 family proteins.Chromosomal instability, tolerance of mitotic errors and multidrug resistance are promoted by tetraploidization in human cells.Regulation of p21 by TWIST2 contributes to its tumor-suppressor function in human acute myeloid leukemia.Expression of the class II tumor suppressor gene RIG1 is directly regulated by p53 tumor suppressor in cancer cell lines.Epstein-Barr virus-encoded LMP1 triggers regulation of the ERK-mediated Op18/stathmin signaling pathway in association with cell cycle.Growth hormone releasing hormone induces the expression of nitric oxide synthase.p53 regulates ERK activation in carboplatin induced apoptosis in cervical carcinoma: a novel target of p53 in apoptosis.ERK1/2 and MEK1/2 induced by Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) early during infection of target cells are essential for expression of viral genes and for establishment of infection.Withdrawal of BDNF from hippocampal cultures leads to changes in genes involved in synaptic function.Regulation of the phosphorylation and integrity of protein synthesis initiation factor eIF4GI and the translational repressor 4E-BP1 by p53.RNA sequencing supports distinct reactive oxygen species-mediated pathways of apoptosis by high and low size mass fractions of Bay leaf (Lauris nobilis) in HT-29 cells.A hemolytic-uremic syndrome-associated strain O113:H21 Shiga toxin-producing Escherichia coli specifically expresses a transcriptional module containing dicA and is related to gene network dysregulation in Caco-2 cells.Dual-specificity phosphatase 5 acts as an anti-inflammatory regulator by inhibiting the ERK and NF-κB signaling pathways.Dual Specificity Phosphatase 5-Substrate Interaction: A Mechanistic Perspective.Genomic and transcriptomic profiles and in vitro resistance to mitoxantrone and idarubicin in pediatric acute leukemias.Microarray-Based Analysis of Spinal versus Intracranial Meningiomas: Different Clinical, Biological, and Genetic Characteristics Associated with Distinct Patterns of Gene Expression

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Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53

http://www.wikidata.org/entity/Q28204132

description

2003 nî lūn-bûn

@nan

2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2003年の論文

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2003年論文

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2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

Dual-specificity phosphatase 5 ...... target of tumor suppressor p53

@ast

Dual-specificity phosphatase 5 ...... target of tumor suppressor p53

@en

Dual-specificity phosphatase 5 ...... target of tumor suppressor p53

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type

label

Dual-specificity phosphatase 5 ...... target of tumor suppressor p53

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Dual-specificity phosphatase 5 ...... target of tumor suppressor p53

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Dual-specificity phosphatase 5 ...... target of tumor suppressor p53

@nl

prefLabel

Dual-specificity phosphatase 5 ...... target of tumor suppressor p53

@ast

Dual-specificity phosphatase 5 ...... target of tumor suppressor p53

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Dual-specificity phosphatase 5 ...... target of tumor suppressor p53

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Dual-specificity phosphatase 5 ...... target of tumor suppressor p53

@en

P2093

Hirofumi Arakawa

http://www.w3.org/2001/XMLSchema#string

Koji Ueda

http://www.w3.org/2001/XMLSchema#string

Yusuke Nakamura

http://www.w3.org/2001/XMLSchema#string

P2860

Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase

Isolation of a novel TP53 target gene from a colon cancer cell line carrying a highly regulated wild-type TP53 expression system

Identification of semaphorin3B as a direct target of p53

Cyclin K as a direct transcriptional target of the p53 tumor suppressor

p53, the cellular gatekeeper for growth and division

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

Definition of a consensus binding site for p53

An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF

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scholarly article

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10.1038/SJ.ONC.1206845

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36

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22

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2003-08-28T00:00:00Z

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10592116

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1016721853

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12944906

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