The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death
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Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitorPim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XLProto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosisPim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cellsThe 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugsPIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancersHonokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosisTricyclic Benzo[cd]azulenes selectively inhibit activities of Pim kinases and restrict growth of Epstein-Barr virus-transformed cellsFlexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitorThe PIM kinases in hematological cancersPim kinase inhibitors: a survey of the patent literatureIncreased expression of the hPim-2 gene in human chronic lymphocytic leukemia and non-Hodgkin lymphomaEvidence that the Pim1 kinase gene is a direct target of HOXA9Pim3 negatively regulates glucose-stimulated insulin secretionPim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasionPIM-1 kinase expression in adipocytic neoplasms: diagnostic and biological implications.Transcriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonistsPharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes.Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.A unified 35-gene signature for both subtype classification and survival prediction in diffuse large B-cell lymphomasMitochondrial integrity: preservation through Akt/Pim-1 kinase signaling in the cardiomyocyteSynergistic interactions with PI3K inhibition that induce apoptosis.Pathophysiological roles of Pim-3 kinase in pancreatic cancer development and progression.Cell and gene therapy for severe heart failure patients: the time and place for Pim-1 kinase.Human embryonic stem cells express elevated levels of multiple pro-apoptotic BCL-2 family members.A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma.Suppression of dendritic cell-mediated responses by genes in calcium and cysteine protease pathways during Mycobacterium tuberculosis infection.Activation of cell cycle arrest and apoptosis by the proto-oncogene Pim-2.Latexin is down-regulated in hematopoietic malignancies and restoration of expression inhibits lymphoma growth.Overexpression of Pim-1 in bladder cancer.A regulatory feedback loop between HIF-1α and PIM2 in HepG2 cellsPim-2/mTORC1 Pathway Shapes Inflammatory Capacity in Rheumatoid Arthritis Synovial Cells Exposed to Lipid Peroxidations.Targeting PIM kinase enhances the activity of sunitinib in renal cell carcinoma.Inhibition of Pim1 kinase activation attenuates allergen-induced airway hyperresponsiveness and inflammationPim Kinase Interacts with Nonstructural 5A Protein and Regulates Hepatitis C Virus Entry.Convergence of TCR and cytokine signaling leads to FOXO3a phosphorylation and drives the survival of CD4+ central memory T cells.The survival kinases Akt and Pim as potential pharmacological targets.Control of Pim2 kinase stability and expression in transformed human haematopoietic cellsActivation of Pim Kinases Is Sufficient to Promote Resistance to MET Small-Molecule Inhibitors.The Pim kinases control rapamycin-resistant T cell survival and activation.
P2860
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P2860
The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death
description
2003 nî lūn-bûn
@nan
2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death
@ast
The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death
@en
The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death
@nl
type
label
The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death
@ast
The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death
@en
The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death
@nl
prefLabel
The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death
@ast
The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death
@en
The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death
@nl
P2093
P3181
P356
P1476
The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death
@en
P2093
Andrew Kraft
Marina Zemskova
Michael Lilly
Paivi J Koskinen
Sheldon Holder
Vernon Chin
P304
P3181
P356
10.1074/JBC.M307933200
P407
P577
2003-11-14T00:00:00Z