ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum
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Identification of human aminopeptidase O, a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolaseRegulation of the human leukocyte-derived arginine aminopeptidase/endoplasmic reticulum-aminopeptidase 2 gene by interferon-gammaMultiple viral ligands naturally presented by different class I molecules in transporter antigen processing-deficient vaccinia virus-infected cellsAn aminopeptidase, ARTS-1, is required for interleukin-6 receptor sheddingHuman leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidasesMajor histocompatibility complex class I molecules expressed with monoglucosylated N-linked glycans bind calreticulin independently of their assembly statusAmyloid precursor-like protein 2 increases the endocytosis, instability, and turnover of the H2-K(d) MHC class I moleculeSpecificity of amyloid precursor-like protein 2 interactions with MHC class I moleculesIntracellular Transport Routes for MHC I and Their Relevance for Antigen Cross-PresentationAlternative Antigen Processing for MHC Class I: Multiple Roads Lead to RomeMechanisms of HIV protein degradation into epitopes: implications for vaccine designWhat is the role of alternate splicing in antigen presentation by major histocompatibility complex class I molecules?Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases.Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimmingThe Peptide-Receptive Transition State of MHC Class I Molecules: Insight from Structure and Molecular DynamicsStructural insights into the molecular ruler mechanism of the endoplasmic reticulum aminopeptidase ERAP1A Naturally Variable Residue in the S1 Subsite of M1 Family Aminopeptidases Modulates Catalytic Properties and Promotes Functional SpecializationRationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responsesFrom HLA-B27 to spondyloarthritis: a journey through the ER.Heteromeric protein complexes mediate zinc transport into the secretory pathway of eukaryotic cells.ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulumThe ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residuesRequirement of the proteasome for the trimming of signal peptide-derived epitopes presented by the nonclassical major histocompatibility complex class I molecule HLA-EDistribution of adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase (ERAP)-1 in human uterine endometriumInvolvement of the V2 receptor in vasopressin-stimulated translocation of placental leucine aminopeptidase/oxytocinase in renal cellsDefective cross-presentation of viral antigens in GILT-free miceImmunoprevention of chemical carcinogenesis through early recognition of oncogene mutationsIdentification and characterization of human leukocyte antigen class I ligands in renal cell carcinoma cellsNonclassical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulumAn endogenous HIV envelope-derived peptide without the terminal NH3+ group anchor is physiologically presented by major histocompatibility complex class I molecules.Two HLA-B14 subtypes (B*1402 and B*1403) differentially associated with ankylosing spondylitis differ substantially in peptide specificity but have limited peptide and T-cell epitope sharing with HLA-B27.Extracellular TNFR1 release requires the calcium-dependent formation of a nucleobindin 2-ARTS-1 complex.EpiJen: a server for multistep T cell epitope prediction.The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.Use of "one-pot, mix-and-read" peptide-MHC class I tetramers and predictive algorithms to improve detection of cytotoxic T lymphocyte responses in cattle.Pathways of antigen processing.Cutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzymeComputational analysis and modeling of cleavage by the immunoproteasome and the constitutive proteasomeEscape mutations alter proteasome processing of major histocompatibility complex class I-restricted epitopes in persistent hepatitis C virus infection.
P2860
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P2860
ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum
@ast
ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum
@en
ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum
@nl
type
label
ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum
@ast
ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum
@en
ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum
@nl
prefLabel
ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum
@ast
ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum
@en
ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum
@nl
P2093
P2860
P3181
P356
P1433
P1476
ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum
@en
P2093
Federico Gonzalez
Jennifer Kim
Nilabh Shastri
Richard Jacob
Thomas Serwold
P2860
P2888
P3181
P356
10.1038/NATURE01074
P407
P577
2002-10-03T00:00:00Z
P5875
P6179
1008307808