ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development
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A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressivaBmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivoBMP type I receptor inhibition reduces heterotopic [corrected] ossificationTGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and diseaseThe biological function of type I receptors of bone morphogenetic protein in boneInteraction of TGFβ and BMP signaling pathways during chondrogenesisClassic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1From mysteries to medicines: drug development for fibrodysplasia ossificans progressiveGene therapy: design and prospects for craniofacial regeneration.The FOP metamorphogene encodes a novel type I receptor that dysregulates BMP signaling.ACVR1 p.Q207E causes classic fibrodysplasia ossificans progressiva and is functionally distinct from the engineered constitutively active ACVR1 p.Q207D variantBMP signaling stimulates cellular differentiation at multiple steps during cartilage development.Cellular and morphological aspects of fibrodysplasia ossificans progressiva. Lessons of formation, repair, and bone bioengineering.Differential expression of the RANKL/RANK/OPG system is associated with bone metastasis in human non-small cell lung cancer.Fibrodysplasia ossificans progressiva: mechanisms and models of skeletal metamorphosisPotent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists.Insights from a rare genetic disorder of extra-skeletal bone formation, fibrodysplasia ossificans progressiva (FOP)Human developmental chondrogenesis as a basis for engineering chondrocytes from pluripotent stem cells.Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femur.Alk2 regulates early chondrogenic fate in fibrodysplasia ossificans progressiva heterotopic endochondral ossificationFibrodysplasia ossificans progressiva: a human genetic disorder of extraskeletal bone formation, or--how does one tissue become another?Role of altered signal transduction in heterotopic ossification and fibrodysplasia ossificans progressiva.The BMP signaling and in vivo bone formationProximal tibial osteochondromas in patients with fibrodysplasia ossificans progressiva.Inherited human diseases of heterotopic bone formation.Common mutations in ALK2/ACVR1, a multi-faceted receptor, have roles in distinct pediatric musculoskeletal and neural orphan disorders.Mutations of TGFbeta signaling molecules in human disease.Skeletal metamorphosis in fibrodysplasia ossificans progressiva (FOP)When one skeleton is enough: approaches and strategies for the treatment of fibrodysplasia ossificans progressiva (FOP).A new era for fibrodysplasia ossificans progressiva: a druggable target for the second skeleton.Severe soft tissue ossification in a southern right whale Eubalaena australisDysregulated BMP signaling and enhanced osteogenic differentiation of connective tissue progenitor cells from patients with fibrodysplasia ossificans progressiva (FOP).The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization.Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification.Non-myogenic Contribution to Muscle Development and Homeostasis: The Role of Connective Tissues.Investigations of activated ACVR1/ALK2, a bone morphogenetic protein type I receptor, that causes fibrodysplasia ossificans progressiva.Epiphyseal growth plate and secondary peripheral chondrosarcoma: the neighbours matter.How do digits emerge? - mathematical models of limb development.Osteochondromas in fibrodysplasia ossificans progressiva: a widespread trait with a streaking but overlooked appearance when arising at femoral bone end.Notch signaling pathway promotes osteogenic differentiation of mesenchymal stem cells by enhancing BMP9/Smad signaling.
P2860
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P2860
ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
ALK2 functions as a BMP type I ...... es during skeletal development
@ast
ALK2 functions as a BMP type I ...... es during skeletal development
@en
ALK2 functions as a BMP type I ...... es during skeletal development
@nl
type
label
ALK2 functions as a BMP type I ...... es during skeletal development
@ast
ALK2 functions as a BMP type I ...... es during skeletal development
@en
ALK2 functions as a BMP type I ...... es during skeletal development
@nl
prefLabel
ALK2 functions as a BMP type I ...... es during skeletal development
@ast
ALK2 functions as a BMP type I ...... es during skeletal development
@en
ALK2 functions as a BMP type I ...... es during skeletal development
@nl
P2093
P2860
P3181
P1476
ALK2 functions as a BMP type I ...... es during skeletal development
@en
P2093
Donghui Zhang
Edward M Schwarz
J Edward Puzas
Michael J Zuscik
Randy N Rosier
Regis J O'Keefe
P2860
P304
P3181
P356
10.1359/JBMR.2003.18.9.1593
P407
P577
2003-09-01T00:00:00Z