The role of dUTPase and uracil-DNA repair in cancer chemotherapy
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A chemogenomic screening of sulfanilamide-hypersensitive Saccharomyces cerevisiae mutants uncovers ABZ2, the gene encoding a fungal aminodeoxychorismate lyaseLinking uracil base excision repair and 5-fluorouracil toxicity in yeastOverview of base excision repair biochemistryDirect contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPasesThe dUTPase enzyme is essential in Mycobacterium smegmatisSAMHD1 protects cancer cells from various nucleoside-based antimetabolites.Stalled replication fork repair and misrepair during thymineless death in Escherichia coli.Disintegration of nascent replication bubbles during thymine starvation triggers RecA- and RecBCD-dependent replication origin destruction.Saccharomyces cerevisiae as a model system to study the response to anticancer agents.A balanced perspective on unbalanced growth and thymineless deathPyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA.Structural insights into the mechanism defining substrate affinity in Arabidopsis thaliana dUTPase: the role of tryptophan 93 in ligand orientation.Commentary: DNA base excision repair defects in human pathologies.In Vitro Analysis of Predicted DNA-Binding Sites for the Stl Repressor of the Staphylococcus aureus SaPIBov1 Pathogenicity Island.Depletion of deoxyribonucleotide pools is an endogenous source of DNA damage in cells undergoing oncogene-induced senescence.Crystallization and preliminary X-ray analysis of three dUTPases from Gram-positive bacteria.Uracil in DNA: consequences for carcinogenesis and chemotherapyUracil DNA glycosylase (UNG) loss enhances DNA double strand break formation in human cancer cells exposed to pemetrexedApoptosis and molecular targeting therapy in cancer.RNA-based 5-fluorouracil toxicity requires the pseudouridylation activity of Cbf5p.A Study of Thymidylate Synthase Expression as a Biomarker for Resectable Colon Cancer: Alliance (Cancer and Leukemia Group B) 9581 and 89803.Cellular response to efficient dUTPase RNAi silencing in stable HeLa cell lines perturbs expression levels of genes involved in thymidylate metabolism.Chemotherapeutic drugs inhibit ribosome biogenesis at various levels.Genome sequence of Perigonia lusca single nucleopolyhedrovirus: insights into the evolution of a nucleotide metabolism enzyme in the family Baculoviridae.dUTPase inhibition augments replication defects of 5-Fluorouracil.Uracil-directed ligand tethering: an efficient strategy for uracil DNA glycosylase (UNG) inhibitor developmentDifferential inhibition of homotrimeric dUTPases by the 3'-azido derivative of dideoxy-UTP.Measuring deaminated nucleotide surveillance enzyme ITPA activity with an ATP-releasing nucleotide chimera.Structural model of human dUTPase in complex with a novel proteinaceous inhibitor.Oxidative Stress-Mediated Overexpression of Uracil DNA Glycosylase in Leishmania donovani Confers Tolerance against Antileishmanial Drugs.Gene dosage effects in yeast support broader roles for the LOG1, HAM1 and DUT1 genes in detoxification of nucleotide analogues.
P2860
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P2860
The role of dUTPase and uracil-DNA repair in cancer chemotherapy
description
2001 nî lūn-bûn
@nan
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
The role of dUTPase and uracil-DNA repair in cancer chemotherapy
@ast
The role of dUTPase and uracil-DNA repair in cancer chemotherapy
@en
The role of dUTPase and uracil-DNA repair in cancer chemotherapy
@nl
type
label
The role of dUTPase and uracil-DNA repair in cancer chemotherapy
@ast
The role of dUTPase and uracil-DNA repair in cancer chemotherapy
@en
The role of dUTPase and uracil-DNA repair in cancer chemotherapy
@nl
prefLabel
The role of dUTPase and uracil-DNA repair in cancer chemotherapy
@ast
The role of dUTPase and uracil-DNA repair in cancer chemotherapy
@en
The role of dUTPase and uracil-DNA repair in cancer chemotherapy
@nl
P3181
P356
P1476
The role of dUTPase and uracil-DNA repair in cancer chemotherapy
@en
P2093
R D Ladner
P304
P3181
P356
10.2174/1389203013380991
P407
P577
2001-12-01T00:00:00Z