Cellular response to efficient dUTPase RNAi silencing in stable HeLa cell lines perturbs expression levels of genes involved in thymidylate metabolism.

Cellular response to efficient dUTPase RNAi silencing in stable HeLa cell lines perturbs expression levels of genes involved in thymidylate metabolism.

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http://www.wikidata.org/entity/Q39502512
Uracil-containing DNA in Drosophila: stability, stage-specific accumulation, and developmental involvementStructure and enzymatic mechanism of a moonlighting dUTPasePhosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insightsThe dUTPase enzyme is essential in Mycobacterium smegmatisCatalytic mechanism of α-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, 31P-NMR spectroscopy and reaction path modelling.Differential control of dNTP biosynthesis and genome integrity maintenance by the dUTPase superfamily enzymes.Life without dUTPase.Preventive DNA repair by sanitizing the cellular (deoxy)nucleoside triphosphate pool.Dynamics of re-constitution of the human nuclear proteome after cell division is regulated by NLS-adjacent phosphorylation.Trading in cooperativity for specificity to maintain uracil-free DNA.dUTPase inhibition augments replication defects of 5-Fluorouracil.Potential steps in the evolution of a fused trimeric all-β dUTPase involve a catalytically competent fused dimeric intermediate.Structural model of human dUTPase in complex with a novel proteinaceous inhibitor.
P2860

Cellular response to efficient dUTPase RNAi silencing in stable HeLa cell lines perturbs expression levels of genes involved in thymidylate metabolism.

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http://www.wikidata.org/entity/Q39502512
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2011 nî lūn-bûn
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2011年の論文
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年學術文章
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Cellular response to efficient ...... ved in thymidylate metabolism.
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Cellular response to efficient ...... ved in thymidylate metabolism.
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Cellular response to efficient ...... ved in thymidylate metabolism.
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Cellular response to efficient ...... ved in thymidylate metabolism.
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Cellular response to efficient ...... ved in thymidylate metabolism.
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Cellular response to efficient ...... ved in thymidylate metabolism.
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Cellular response to efficient ...... lved in thymidylate metabolism
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10.1080/15257770.2011.582849
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