P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium - Wikidata - awgldk - TriplyDB

P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium

P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium

http://www.wikidata.org/entity/Q28206589

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CRIPak, a novel endogenous Pak1 inhibitor Pak1 and PIX regulate contact inhibition during epithelial wound healing PKA-induced resistance to tamoxifen is associated with an altered orientation of ERalpha towards co-activator SRC-1 p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate GPR30: A G protein-coupled receptor for estrogen p21-activated kinase signaling in breast cancer Approaches of targeting Rho GTPases in cancer drug discovery Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells Metastasis-associated protein 2 is a repressor of estrogen receptor alpha whose overexpression leads to estrogen-independent growth of human breast cancer cells Molecular pathways: targeting p21-activated kinase 1 signaling in cancer--opportunities, challenges, and limitations p21-activated kinase group II small compound inhibitor GNE-2861 perturbs estrogen receptor alpha signaling and restores tamoxifen-sensitivity in breast cancer cells Serine 28 phosphorylation of NRIF3 confers its co-activator function for estrogen receptor-alpha transactivation Phosphorylation-dependent regulation of stability and transforming potential of ETS transcriptional factor ESE-1 by p21-activated kinase 1 PAK signalling during the development and progression of cancer Loss of Rho GDIα and resistance to tamoxifen via effects on estrogen receptor α PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion.Identification of phosphorylation sites in betaPIX and PAK1 Inhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer.Pathways to tamoxifen resistance.Systematic mapping of posttranslational modifications in human estrogen receptor-alpha with emphasis on novel phosphorylation sites Minireview: Tipping the balance: ligand-independent activation of steroid receptors.CARM1 mediates the ligand-independent and tamoxifen-resistant activation of the estrogen receptor alpha by cAMP Estrogen receptor mutations and changes in downstream gene expression and signaling A hypersensitive estrogen receptor alpha mutation that alters dynamic protein interactions Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1.Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions Xanthohumol suppresses oestrogen-signalling in breast cancer through the inhibition of BIG3-PHB2 interactions.Active p21-activated kinase 1 rescues MCF10A breast epithelial cells from undergoing anoikis.Liganded and unliganded activation of estrogen receptor and hormone replacement therapies.PAK1 as a therapeutic target.Glyceollin, a novel regulator of mTOR/p70S6 in estrogen receptor positive breast cancer.Therapeutic advances in BIG3-PHB2 inhibition targeting the crosstalk between estrogen and growth factors in breast cancer p21-Activated Kinases 1, 2 and 4 in Endometrial Cancers: Effects on Clinical Outcomes and Cell Proliferation.Growth factor-induced resistance to tamoxifen is associated with a mutation of estrogen receptor alpha and its phosphorylation at serine 305.Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma.Association between the estrogen receptor alpha A908G mutation and outcomes in invasive breast cancer.Mechanisms of Chlamydia trachomatis entry into nonphagocytic cells.

P2860

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P2860

P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium

http://www.wikidata.org/entity/Q28206589

description

2002 nî lūn-bûn

@nan

2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2002年の論文

@ja

2002年論文

@yue

2002年論文

@zh-hant

2002年論文

@zh-hk

2002年論文

@zh-mo

2002年論文

@zh-tw

2002年论文

@wuu

name

P21-activated kinase-1 phospho ...... erplasia in mammary epithelium

@ast

P21-activated kinase-1 phospho ...... erplasia in mammary epithelium

@en

P21-activated kinase-1 phospho ...... erplasia in mammary epithelium

@nl

type

label

P21-activated kinase-1 phospho ...... erplasia in mammary epithelium

@ast

P21-activated kinase-1 phospho ...... erplasia in mammary epithelium

@en

P21-activated kinase-1 phospho ...... erplasia in mammary epithelium

@nl

prefLabel

P21-activated kinase-1 phospho ...... erplasia in mammary epithelium

@ast

P21-activated kinase-1 phospho ...... erplasia in mammary epithelium

@en

P21-activated kinase-1 phospho ...... erplasia in mammary epithelium

@nl

P1433

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P2860

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P3181

P356

P1433

The EMBO Journal

P1476

P21-activated kinase-1 phospho ...... erplasia in mammary epithelium

@en

P2093

Abhijit Mazumdar

http://www.w3.org/2001/XMLSchema#string

Rakesh Kumar

http://www.w3.org/2001/XMLSchema#string

Ratna K Vadlamudi

http://www.w3.org/2001/XMLSchema#string

Rui-An Wang

http://www.w3.org/2001/XMLSchema#string

P2860

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance

Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1

Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor

Pak to the future

Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7

Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells

p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells

P304

5437-47

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P31

scholarly article

P3181

1612601

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P356

10.1093/EMBOJ/CDF543

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P407

P433

20

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P478

21

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P577

2002-10-15T00:00:00Z

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277419449

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P698

12374744

http://www.w3.org/2001/XMLSchema#string

P921

phosphorylation

P932

129075

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