Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase
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WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransportersThe WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transportersStructural insights into the recognition of substrates and activators by the OSR1 kinaseFunctional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1WNK kinases, renal ion transport and hypertensionCloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoformWNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cellsK-Cl cotransporters, cell volume homeostasis, and neurological diseaseConsiderations when quantitating protein abundance by immunoblotCrystal structure of domain-swapped STE20 OSR1 kinase domainThe Na+:Cl- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletionIdentification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lensesThe WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinasesThe Ste20 kinases Ste20-related proline-alanine-rich kinase and oxidative-stress response 1 regulate NKCC1 function in sensory neuronsA SPAK isoform switch modulates renal salt transport and blood pressureBehavioral analysis of Ste20 kinase SPAK knockout mice.Interactive contribution of serine/threonine kinase 39 gene multiple polymorphisms to hypertension among northeastern Han Chinese.A novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters.Multiple pathways for protein phosphatase 1 (PP1) regulation of Na-K-2Cl cotransporter (NKCC1) function: the N-terminal tail of the Na-K-2Cl cotransporter serves as a regulatory scaffold for Ste20-related proline/alanine-rich kinase (SPAK) AND PP1.A novel regulatory locus of phosphorylation in the C terminus of the potassium chloride cotransporter KCC2 that interferes with N-ethylmaleimide or staurosporine-mediated activation.In silico analysis and experimental verification of OSR1 kinase - Peptide interaction.Chloride regulation in the pain pathwayWNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability.On the substrate recognition and negative regulation of SPAK, a kinase modulating Na+-K+-2Cl- cotransport activityRegulation of with-no-lysine kinase signaling by Kelch-like proteins.Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.Short forms of Ste20-related proline/alanine-rich kinase (SPAK) in the kidney are created by aspartyl aminopeptidase (Dnpep)-mediated proteolytic cleavage.SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction.Altered expression of regulators of the cortical chloride transporters NKCC1 and KCC2 in schizophrenia.WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.Housing and husbandry of Xenopus laevis affect the quality of oocytes for heterologous expression studies.The WNKs: atypical protein kinases with pleiotropic actions.Apoptosis-associated tyrosine kinase scaffolding of protein phosphatase 1 and SPAK reveals a novel pathway for Na-K-2C1 cotransporter regulation.Calcium-sensing receptor abrogates secretagogue- induced increases in intestinal net fluid secretion by enhancing cyclic nucleotide destructionSTE20/SPS1-related proline/alanine-rich kinase is involved in plasticity of GABA signaling function in a mouse model of acquired epilepsy.High brain ammonia tolerance and down-regulation of Na+:K+:2Cl(-) Cotransporter 1b mRNA and protein expression in the brain of the Swamp Eel, Monopterus albus, exposed to environmental ammonia or terrestrial conditions.Transcriptomics of salinity tolerance capacity in Arctic charr (Salvelinus alpinus): a comparison of gene expression profiles between divergent QTL genotypes.STE20/SPS1-related proline/alanine-rich kinase (SPAK) is critical for sodium reabsorption in isolated, perfused thick ascending limb.SPAK-mediated NCC regulation in response to low-K+ dietWith-No-Lysine Kinase 3 (WNK3) stimulates glioma invasion by regulating cell volume
P2860
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P2860
Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase
description
2003 nî lūn-bûn
@nan
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Characterization of the intera ...... scaffolding role of the kinase
@ast
Characterization of the intera ...... scaffolding role of the kinase
@en
Characterization of the intera ...... scaffolding role of the kinase
@nl
type
label
Characterization of the intera ...... scaffolding role of the kinase
@ast
Characterization of the intera ...... scaffolding role of the kinase
@en
Characterization of the intera ...... scaffolding role of the kinase
@nl
prefLabel
Characterization of the intera ...... scaffolding role of the kinase
@ast
Characterization of the intera ...... scaffolding role of the kinase
@en
Characterization of the intera ...... scaffolding role of the kinase
@nl
P2093
P2860
P921
P3181
P356
P1476
Characterization of the intera ...... scaffolding role of the kinase
@en
P2093
Eric Delpire
Kerstin Piechotta
Roger England
P2860
P304
52848-52856
P3181
P356
10.1074/JBC.M309436200
P407
P577
2003-10-16T00:00:00Z