WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. - Wikidata - awgldk - TriplyDB

WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.

WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.

http://www.wikidata.org/entity/Q34464530

about

WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters Large-scale proteomics and phosphoproteomics of urinary exosomes Structural insights into the recognition of substrates and activators by the OSR1 kinase Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1 Molecular physiology of the thiazide-sensitive sodium-chloride cotransporter Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics Large-scale phosphoproteomic analysis of membrane proteins in renal proximal and distal tubule The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway WNK kinases, renal ion transport and hypertension Renal and brain isoforms of WNK3 have opposite effects on NCCT expression Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells A molecular update on pseudohypoaldosteronism type II Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation Small-molecule WNK inhibition regulates cardiovascular and renal function Crystal structure of domain-swapped STE20 OSR1 kinase domain Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK The Na+:Cl- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion Thick ascending limb: the Na(+):K (+):2Cl (-) co-transporter, NKCC2, and the calcium-sensing receptor, CaSR A role for the circadian clock protein Per1 in the regulation of the NaCl co-transporter (NCC) and the with-no-lysine kinase (WNK) cascade in mouse distal convoluted tubule cells Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses The Ste20 kinases Ste20-related proline-alanine-rich kinase and oxidative-stress response 1 regulate NKCC1 function in sensory neurons Regulation of NKCC2 activity by inhibitory SPAK isoforms: KS-SPAK is a more potent inhibitor than SPAK2 Structural and biochemical insights into the activation mechanisms of germinal center kinase OSR1.From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.Behavioral analysis of Ste20 kinase SPAK knockout mice.Phorbol 12-myristate 13-acetate-induced endocytosis of the Na-K-2Cl cotransporter in MDCK cells is associated with a clathrin-dependent pathway WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration.Phosphorylation and transport in the Na-K-2Cl cotransporters, NKCC1 and NKCC2A, compared in HEK-293 cells.Kinome-wide RNAi screen implicates at least 5 host hepatocyte kinases in Plasmodium sporozoite infection.STK39 polymorphisms and blood pressure: an association study in British Caucasians and assessment of cis-acting influences on gene expression.Sympathetic stimulation of thiazide-sensitive sodium chloride cotransport in the generation of salt-sensitive hypertension.Multiple pathways for protein phosphatase 1 (PP1) regulation of Na-K-2Cl cotransporter (NKCC1) function: the N-terminal tail of the Na-K-2Cl cotransporter serves as a regulatory scaffold for Ste20-related proline/alanine-rich kinase (SPAK) AND PP1.Chloride regulation in the pain pathway

P2860

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P2860

WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.

http://www.wikidata.org/entity/Q34464530

description

2005 nî lūn-bûn

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2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2005 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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name

WNK1 regulates phosphorylation ...... elated kinases, SPAK and OSR1.

@ast

WNK1 regulates phosphorylation ...... elated kinases, SPAK and OSR1.

@en

WNK1 regulates phosphorylation ...... elated kinases, SPAK and OSR1.

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type

label

WNK1 regulates phosphorylation ...... elated kinases, SPAK and OSR1.

@ast

WNK1 regulates phosphorylation ...... elated kinases, SPAK and OSR1.

@en

WNK1 regulates phosphorylation ...... elated kinases, SPAK and OSR1.

@nl

prefLabel

WNK1 regulates phosphorylation ...... elated kinases, SPAK and OSR1.

@ast

WNK1 regulates phosphorylation ...... elated kinases, SPAK and OSR1.

@en

WNK1 regulates phosphorylation ...... elated kinases, SPAK and OSR1.

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P1433

Journal of Biological Chemistry

P1476

WNK1 regulates phosphorylation ...... elated kinases, SPAK and OSR1.

@en

P2093

Hiroshi Shibuya

http://www.w3.org/2001/XMLSchema#string

Kunihiro Matsumoto

http://www.w3.org/2001/XMLSchema#string

Naoki Hisamoto

http://www.w3.org/2001/XMLSchema#string

Seiichi Urushiyama

http://www.w3.org/2001/XMLSchema#string

Shinichi Uchida

http://www.w3.org/2001/XMLSchema#string

Shun-ichiro Iemura

http://www.w3.org/2001/XMLSchema#string

Tetsuo Moriguchi

http://www.w3.org/2001/XMLSchema#string

Tohru Natsume

http://www.w3.org/2001/XMLSchema#string

P2860

WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding

Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily

Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4

WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia

Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins

PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1)

The Na-K-Cl cotransporter of secretory epithelia

WNK kinases, a novel protein kinase subfamily in multi-cellular organisms

Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family

Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase

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42685-42693

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10.1074/JBC.M510042200

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P433

52

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280

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2005-10-31T00:00:00Z

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16263722

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P921

phosphorylation