High-resolution NMR structure of the chemically-synthesized melanocortin receptor binding domain AGRP(87-132) of the agouti-related protein
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Structural and molecular evolutionary analysis of Agouti and Agouti-related proteinsLoop-Swapped Chimeras of the Agouti-Related Protein and the Agouti Signaling Protein Identify Contacts Required for Melanocortin 1 Receptor Selectivity and AntagonismAlternative binding proteins: biological activity and therapeutic potential of cystine-knot miniproteins.Transient ectopic overexpression of agouti-signalling protein 1 (asip1) induces pigment anomalies in flatfish.Solid-phase peptide head-to-side chain cyclodimerization: discovery of C(2)-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptorsGenetic and biochemical studies of the Agouti-attractin system.Cyclic lactam hybrid α-MSH/Agouti-related protein (AGRP) analogues with nanomolar range binding affinities at the human melanocortin receptorsDiscovery of a β-Hairpin Octapeptide, c[Pro-Arg-Phe-Phe-Dap-Ala-Phe-DPro], Mimetic of Agouti-Related Protein(87-132) [AGRP(87-132)] with Equipotent Mouse Melanocortin-4 Receptor (mMC4R) Antagonist Pharmacology.Agouti-related protein segments outside of the receptor binding core are required for enhanced short- and long-term feeding stimulationA Macrocyclic Agouti-Related Protein/[Nle4,DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Subnanomolar Melanocortin Receptor Ligands.Chemical disulfide mapping identifies an inhibitor cystine knot in the agouti signaling protein.The agouti-related peptide binds heparan sulfate through segments critical for its orexigenic effects.New ligands for melanocortin receptors.Engineered cystine-knot miniproteins for diagnostic applications.Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016.Pharmacological characterization of 30 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists, synthetic agonists, and the endogenous agouti-related protein antagonist.Grafting of thrombopoietin-mimetic peptides into cystine knot miniproteins yields high-affinity thrombopoietin antagonists and agonists.Dap-SL: a new site-directed nitroxide spin labeling approach for determining structure and motions in synthesized peptides and proteins.Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist PharmacologSynthetic Cystine-Knot Miniproteins - Valuable Scaffolds for Polypeptide Engineering.
P2860
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P2860
High-resolution NMR structure of the chemically-synthesized melanocortin receptor binding domain AGRP(87-132) of the agouti-related protein
description
2001 nî lūn-bûn
@nan
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
High-resolution NMR structure ...... of the agouti-related protein
@ast
High-resolution NMR structure ...... of the agouti-related protein
@en
High-resolution NMR structure ...... of the agouti-related protein
@nl
type
label
High-resolution NMR structure ...... of the agouti-related protein
@ast
High-resolution NMR structure ...... of the agouti-related protein
@en
High-resolution NMR structure ...... of the agouti-related protein
@nl
prefLabel
High-resolution NMR structure ...... of the agouti-related protein
@ast
High-resolution NMR structure ...... of the agouti-related protein
@en
High-resolution NMR structure ...... of the agouti-related protein
@nl
P2093
P356
P1433
P1476
High-resolution NMR structure ...... of the agouti-related protein
@en
P2093
D A Thompson
G L Millhauser
J C McNulty
P304
P356
10.1021/BI0117192
P407
P577
2001-12-25T00:00:00Z