Grafting of thrombopoietin-mimetic peptides into cystine knot miniproteins yields high-affinity thrombopoietin antagonists and agonists.
about
Alternative binding proteins: biological activity and therapeutic potential of cystine-knot miniproteins.F104S c-Mpl responds to a transmembrane domain-binding thrombopoietin receptor agonist: proof of concept that selected receptor mutations in congenital amegakaryocytic thrombocytopenia can be stimulated with alternative thrombopoietic agents.Engineered cystine knot peptides that bind alphavbeta3, alphavbeta5, and alpha5beta1 integrins with low-nanomolar affinity.Interrogating and predicting tolerated sequence diversity in protein folds: application to E. elaterium trypsin inhibitor-II cystine-knot miniproteinCystine-knot peptides engineered with specificities for α(IIb)β(3) or α(IIb)β(3) and α(v)β(3) integrins are potent inhibitors of platelet aggregation.Functional mutation of multiple solvent-exposed loops in the Ecballium elaterium trypsin inhibitor-II cystine knot miniprotein.Protease-resistant peptide ligands from a knottin scaffold library.Receptor-targeting mechanisms of pain-causing toxins: How ow?Polycyclic peptide therapeutics.Cystine-knot peptides targeting cancer-relevant human cytotoxic T lymphocyte-associated antigen 4 (CTLA-4).KNOTTIN: the knottin or inhibitor cystine knot scaffold in 2007Understanding cytokine and growth factor receptor activation mechanisms.Engineered cystine-knot miniproteins for diagnostic applications.Nucleic acid and peptide aptamers: fundamentals and bioanalytical aspects.Chemical synthesis, backbone cyclization and oxidative folding of cystine-knot peptides: promising scaffolds for applications in drug design.Cystine-knot peptides: emerging tools for cancer imaging and therapy.Cellular uptake of a cystine-knot peptide and modulation of its intracellular trafficking.A chemically cross-linked knottin dimer binds integrins with picomolar affinity and inhibits tumor cell migration and proliferation.Anti-angiogenic effects of two cystine-knot miniproteins from tomato fruit.Easy and rapid binding assay for functional analysis of disulfide-containing peptides by a pull-down method using a puromycin-linker and a cell-free translation system.Synthetic Cystine-Knot Miniproteins - Valuable Scaffolds for Polypeptide Engineering.Interface Peptides
P2860
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P2860
Grafting of thrombopoietin-mimetic peptides into cystine knot miniproteins yields high-affinity thrombopoietin antagonists and agonists.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Grafting of thrombopoietin-mim ...... etin antagonists and agonists.
@en
type
label
Grafting of thrombopoietin-mim ...... etin antagonists and agonists.
@en
prefLabel
Grafting of thrombopoietin-mim ...... etin antagonists and agonists.
@en
P2093
P2860
P1433
P1476
Grafting of thrombopoietin-mim ...... etin antagonists and agonists.
@en
P2093
Alexander Wentzel
Hans-Ulrich Schmoldt
Harald Kolmar
Karlheinz Friedrich
Matthias Ballmaier
Sebastian Krause
P2860
P356
10.1111/J.1742-4658.2006.05567.X
P407
P577
2006-11-27T00:00:00Z