Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth
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Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascadeEvidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivoMO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasmActivation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRADSIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activationCharacterization of an alternative splice variant of LKB1WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrateHeat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stabilityMSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblastsAmino acids as regulators of gene expressionFibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathwayActivation and function of the MAPKs and their substrates, the MAPK-activated protein kinasesLKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndromeRefinement and prediction of protein prenylation motifsLKB1 associates with Brg1 and is necessary for Brg1-induced growth arrestLKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domainUncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAFIonizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366Contrasting roles of neuronal Msk1 and Rsk2 in Bad phosphorylation and feedback regulation of Erk signallingNeuregulin signaling on glucose transport in muscle cellsIdentification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndromeLKB1 regulates TCR-mediated PLCĪ³1 activation and thymocyte positive selectionInvestigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activityERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functionsDevelopment of a RSK Inhibitor as a Novel Therapy for Triple-Negative Breast Cancer.Regulation of LKB1/STRAD localization and function by E-cadherin.LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues.Bi-functional, substrate mimicking RNA inhibits MSK1-mediated cAMP-response element-binding protein phosphorylation and reveals magnesium ion-dependent conformational changes of the kinase.PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysisPhosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells.Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression.Targeted therapies of the LKB1/AMPK pathway for the treatment of insulin resistanceRegulation of bile canalicular network formation and maintenance by AMP-activated protein kinase and LKB1.LKB1 is required for adiponectin-mediated modulation of AMPK-S6K axis and inhibition of migration and invasion of breast cancer cellsInduction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis.Metastasis suppression by adiponectin: LKB1 rises up to the challenge.Endurance training increases LKB1 and MO25 protein but not AMP-activated protein kinase kinase activity in skeletal muscle.Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function.The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) miceLovastatin induces multiple stress pathways including LKB1/AMPK activation that regulate its cytotoxic effects in squamous cell carcinoma cells.
P2860
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P2860
Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth
description
2001 nĆ® lÅ«n-bĆ»n
@nan
2001 Õ©ÕøÖÕ”ÕÆÕ”Õ¶Õ« Õ
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Õ¤ÕøÖÕ”Õ®
@hyw
2001 Õ©Õ¾Õ”ÕÆÕ”Õ¶Õ« Õ°ÕøÖÕ¶Õ«Õ½Õ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕ¾Õ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ Õ°ÕøÕ¤Õ¾Õ”Õ®
@hy
2001幓ć®č«ę
@ja
2001幓č«ę
@yue
2001幓č«ę
@zh-hant
2001幓č«ę
@zh-hk
2001幓č«ę
@zh-mo
2001幓č«ę
@zh-tw
2001幓č®ŗę
@wuu
name
Phosphorylation of the protein ...... r LKB1 to suppress cell vrowth
@ast
Phosphorylation of the protein ...... r LKB1 to suppress cell vrowth
@en
Phosphorylation of the protein ...... r LKB1 to suppress cell vrowth
@nl
type
label
Phosphorylation of the protein ...... r LKB1 to suppress cell vrowth
@ast
Phosphorylation of the protein ...... r LKB1 to suppress cell vrowth
@en
Phosphorylation of the protein ...... r LKB1 to suppress cell vrowth
@nl
prefLabel
Phosphorylation of the protein ...... r LKB1 to suppress cell vrowth
@ast
Phosphorylation of the protein ...... r LKB1 to suppress cell vrowth
@en
Phosphorylation of the protein ...... r LKB1 to suppress cell vrowth
@nl
P2093
P2860
P50
P3181
P356
P1476
Phosphorylation of the protein ...... r LKB1 to suppress cell vrowth
@en
P2093
P2860
P304
19469-19482
P3181
P356
10.1074/JBC.M009953200
P407
P577
2001-01-31T00:00:00Z