Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity
about
Sequence changes in predicted promoter elements of STK11/LKB1 are unlikely to contribute to Peutz-Jeghers syndromeLKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivoLKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndromeHow microRNAs influence both hereditary and inflammatory-mediated colon cancersRegulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1Mutation screening at the RNA level of the STK11/LKB1 gene in Peutz-Jeghers syndrome reveals complex splicing abnormalities and a novel mRNA isoform (STK11 c.597(insertion mark)598insIVS4)Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowthA role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndromeIdentification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndromeUpdate on our investigation of malignant tumors associated with Peutz-Jeghers syndrome in Japan.A novel mutation in STK11 gene is associated with Peutz-Jeghers Syndrome in Indian patients.Genetic testing for hereditary colorectal cancer.AMPK activation--protean potential for boosting healthspan.High prevalence of germline STK11 mutations in Hungarian Peutz-Jeghers Syndrome patients.A novel mutation in STK11 gene is associated with Peutz-Jeghers syndrome in Chinese patients.Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis.Clinical genetics of multiple endocrine neoplasias, Carney complex and related syndromes.The LKB1 tumor suppressor controls spindle orientation and localization of activated AMPK in mitotic epithelial cells.Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function.The phenotypic spectrum of GLI3 morphopathies includes autosomal dominant preaxial polydactyly type-IV and postaxial polydactyly type-A/B; No phenotype prediction from the position of GLI3 mutations.Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrestSTK11/LKB1 germline mutations are not identified in most Peutz-Jeghers syndrome patients.Peutz-Jeghers families unlinked to STK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinomaLKB1, a protein kinase regulating cell proliferation and polarity.Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome.Genotype-phenotype correlations in Peutz-Jeghers syndromeFunctional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.Liver kinase B1 (LKB1) in the pathogenesis of epithelial cancersEndopancreatic bile duct cholangiocarcinoma in a patient with peutz-jeghers syndrome.5'-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer.Cancer risks in LKB1 germline mutation carriers.[Peutz-Jeghers syndrome, about 3 cases in siblings].The differential diagnosis of familial lentiginosis syndromesThree novel mutations of STK11 gene in Chinese patients with Peutz-Jeghers syndrome.Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.AMPK and cell proliferation--AMPK as a therapeutic target for atherosclerosis and cancer.Novel serine/threonine kinase 11 gene mutations in Peutz-Jeghers syndrome patients and endoscopic managementCongenital disease SNPs target lineage specific structural elements in protein kinasesGenetic defects underlying Peutz-Jeghers syndrome (PJS) and exclusion of the polarity-associated MARK/Par1 gene family as potential PJS candidates.Genetic Screening and Analysis of LKB1 Gene in Chinese Patients with Peutz-Jeghers Syndrome.
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P2860
Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Loss of LKB1 kinase activity i ...... llelic and locus heterogeneity
@ast
Loss of LKB1 kinase activity i ...... llelic and locus heterogeneity
@en
Loss of LKB1 kinase activity i ...... llelic and locus heterogeneity
@nl
type
label
Loss of LKB1 kinase activity i ...... llelic and locus heterogeneity
@ast
Loss of LKB1 kinase activity i ...... llelic and locus heterogeneity
@en
Loss of LKB1 kinase activity i ...... llelic and locus heterogeneity
@nl
prefLabel
Loss of LKB1 kinase activity i ...... llelic and locus heterogeneity
@ast
Loss of LKB1 kinase activity i ...... llelic and locus heterogeneity
@en
Loss of LKB1 kinase activity i ...... llelic and locus heterogeneity
@nl
P2093
P2860
P3181
P356
P1476
Loss of LKB1 kinase activity i ...... llelic and locus heterogeneity
@en
P2093
J L Blouin
P2860
P304
P3181
P356
10.1086/302159
P407
P577
1998-12-01T00:00:00Z