Generating diverse skeletons of small molecules combinatorially
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A small molecule that binds Hedgehog and blocks its signaling in human cellsTowards the optimal screening collection: a synthesis strategyConstruction of functionalized tricyclic dihydropyrazino-quinazolinedione chemotypes via an Ugi/N-acyliminium ion cyclization cascade.Domain-based small molecule binding site annotationFluorous mixture synthesis of two libraries with hydantoin-, and benzodiazepinedione-fused heterocyclic scaffolds.Rapid synthesis of diketopiperazine macroarrays via Ugi four-component reactions on planar solid supportsA unified synthetic approach to polyketides having both skeletal and stereochemical diversity.Synthesis of unprecedented scaffold diversity.Construction of a bicyclic beta-benzyloxy and beta-hydroxy amide library through a multicomponent cyclization reactionThe tert-butylsulfinamide lynchpin in transition-metal-mediated multiscaffold library synthesis.Proteomic and genetic approaches identify Syk as an AML target.Natural Products as a Foundation for Drug Discovery.Diversity through a branched reaction pathway: generation of multicyclic scaffolds and identification of antimigratory agents.Challenges of antibacterial discoveryDesign, synthesis, and biological evaluation of a biyouyanagin compound libraryIncreased diversity of libraries from libraries: chemoinformatic analysis of bis-diazacyclic libraries.Diversity-oriented synthesis of macrocyclic peptidomimetics.Branching cascades: a concise synthetic strategy targeting diverse and complex molecular frameworks.Towards the systematic exploration of chemical space.Small-molecule modulators of the Sonic Hedgehog signaling pathway.New mimetic peptides of the kinase-inhibitory region (KIR) of SOCS1 through focused peptide libraries.Nitroso Diels-Alder (NDA) reaction as an efficient tool for the functionalization of diene-containing natural products1,2,4-trisubstituted cyclopentanes as platforms for diversity.Natural products: a continuing source of novel drug leadsA two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds.Are natural products still the best source for antibacterial discovery? The bacterial entry factor.Is synthesis the main hurdle for the generation of diversity in compound libraries for screening?Synthesis of skeletally diverse and stereochemically complex library templates derived from isosteviol and steviolEmulating the logic of monoterpenoid alkaloid biogenesis to access a skeletally diverse chemical library.A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling.Scaling out by microwave-assisted, continuous flow organic synthesis (MACOS): multi-gram synthesis of bromo- and fluoro-benzofused sultams benzthiaoxazepine-1,1-dioxidesAccessing Stereochemically Rich Sultams via Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS) Scale-out.De novo branching cascades for structural and functional diversity in small molecules.Carbohydrates in diversity-oriented synthesis: challenges and opportunities.Exploring biology with small organic molecules.Asymmetric multicomponent reactions (AMCRs): the new frontier.Chemical approaches to the discovery and development of cancer therapies.Development of a Terpenoid Alkaloid-like Compound Library Based on the Humulene Skeleton.Novel Glycopyrrolidine Compounds Inhibit Human Cancer Cell Proliferation and Induce Apoptotic Mode of Cell Death.Skeletal and Appendage Diversity as Design Elements in the Synthesis of a Discovery Library of Nonaromatic Polycyclic 5-Iminooxazolidin-2-ones, Hydantoins, and Acylureas.
P2860
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P2860
Generating diverse skeletons of small molecules combinatorially
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Generating diverse skeletons of small molecules combinatorially
@ast
Generating diverse skeletons of small molecules combinatorially
@en
Generating diverse skeletons of small molecules combinatorially
@nl
type
label
Generating diverse skeletons of small molecules combinatorially
@ast
Generating diverse skeletons of small molecules combinatorially
@en
Generating diverse skeletons of small molecules combinatorially
@nl
prefLabel
Generating diverse skeletons of small molecules combinatorially
@ast
Generating diverse skeletons of small molecules combinatorially
@en
Generating diverse skeletons of small molecules combinatorially
@nl
P2093
P356
P1433
P1476
Generating diverse skeletons of small molecules combinatorially
@en
P2093
Eric M Berger
Martin D Burke
Stuart L Schreiber
P356
10.1126/SCIENCE.1089946
P407
P577
2003-10-24T00:00:00Z