Chemical approaches to the discovery and development of cancer therapies.
about
Not so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystalIntercalator conjugates of pyrimidine locked nucleic acid-modified triplex-forming oligonucleotides: improving DNA binding properties and reaching cellular activities.Sequence- and structural-selective nucleic acid binding revealed by the melting of mixtures.Using Pharmacogenomic Databases for Discovering Patient-Target Genes and Small Molecule Candidates to Cancer TherapyRe-directing an alkylating agent to mitochondria alters drug target and cell death mechanismEarly Chk1 phosphorylation is driven by temozolomide-induced, DNA double strand break- and mismatch repair-independent DNA damageA New Epigenetic Mechanism of Temozolomide Action in Glioma CellsAtomic force microscopy study of the specific adhesion between a colloid particle and a living melanoma cell: Effect of the charge and the hydrophobicity of the particle surfaceStructural insight for the recognition of G-quadruplex structure at human c-myc promoter sequence by flavonoid QuercetinSynthesis and Evaluation of Haloacetyl, α-Bromoacryloyl and Nitrooxyacetyl Benzo[b]furan and Benzo[b]thiophene Derivatives as Potent Antiproliferative Agents Against Leukemia L1210 and K562 Cells.A novel bisindole-PBD conjugate causes DNA damage induced apoptosis via inhibition of DNA repair pathway."One ring to bind them all"-part I: the efficiency of the macrocyclic scaffold for g-quadruplex DNA recognition.Molecular docking studies of anti-cancerous candidates in Hippophae rhamnoides and Hippophae salicifoliaEthyl 1,6-dimethyl-2-oxo-4-(quinolin-4-yl)-1,2,3,4-tetra-hydro-pyrimidine-5-carboxyl-ate.Novel G-quadruplex stabilizing agents: in-silico approach and dynamics.A Discovery Funnel for Nucleic Acid Binding Drug CandidatesIdentification of new natural DNA G-quadruplex binders selected by a structure-based virtual screening approach.Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists.Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cellsAntiproliferative activities of halogenated thieno[3,2-d]pyrimidinesSynthesis and DNA-binding affinity studies of glycosylated intercalators designed as functional mimics of the anthracycline antibioticsAntiprotease therapy in cancer: hot or not?Temperature-feedback upconversion nanocomposite for accurate photothermal therapy at facile temperature.Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia.Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1)A hitchhiker's guide to G-quadruplex ligands.Novel metals and metal complexes as platforms for cancer therapyDirect detection and quantification of abasic sites for in vivo studies of DNA damage and repair.Discovery of 8-methoxypyrazino[1,2-a]indole as a New Potent Antiproliferative Agent Against Human Leukemia K562 Cells. A Structure-Activity Relationship Study.Heterocyclic dications as a new class of telomeric G-quadruplex targeting agentsA selective and label-free strategy for rapid screening of telomere-binding Ligands via fluorescence regulation of DNA/silver nanoclusterAn efficient and practical radiosynthesis of [11C]temozolomide.Treatment of pituitary neoplasms with temozolomide: a review.Receptor-targeted nanocarriers for therapeutic delivery to cancer.Temozolomide responsiveness in aggressive corticotroph tumours: a case report and review of the literature.Temozolomide in aggressive pituitary adenomas and carcinomas.Recent advances in the development of 1,8-naphthalimide based DNA targeting binders, anticancer and fluorescent cellular imaging agents.Molecular basis of pharmacological therapy in Cushing's disease.A novel G-quadruplex-forming GGA repeat region in the c-myb promoter is a critical regulator of promoter activity.Interaction between cationic zinc porphyrin and lead ion induced telomeric guanine quadruplexes: evidence for end-stacking.
P2860
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P2860
Chemical approaches to the discovery and development of cancer therapies.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Chemical approaches to the discovery and development of cancer therapies.
@ast
Chemical approaches to the discovery and development of cancer therapies.
@en
type
label
Chemical approaches to the discovery and development of cancer therapies.
@ast
Chemical approaches to the discovery and development of cancer therapies.
@en
prefLabel
Chemical approaches to the discovery and development of cancer therapies.
@ast
Chemical approaches to the discovery and development of cancer therapies.
@en
P2860
P356
P1476
Chemical approaches to the discovery and development of cancer therapies.
@en
P2093
David E Thurston
Stephen Neidle
P2860
P2888
P304
P356
10.1038/NRC1587
P407
P577
2005-04-01T00:00:00Z