Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function - Wikidata - awgldk - TriplyDB

Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function

Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function

http://www.wikidata.org/entity/Q28212296

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Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts Stra13 is induced by genotoxic stress and regulates ionizing-radiation-induced apoptosis Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway Nur77 upregulates HIF-alpha by inhibiting pVHL-mediated degradation Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers The Role of Oxygen Sensors, Hydroxylases, and HIF in Cardiac Function and Disease HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression Therapeutic considerations for Mdm2: not just a one trick pony A Novel Interaction between TFII-I and Mdm2 with a Negative Effect on TFII-I Transcriptional Activity Hypoxia-inducible factor-1alpha is a critical mediator of hypoxia induced apoptosis in cardiac H9c2 and kidney epithelial HK-2 cells.TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer.Regulation of G(1) arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation.p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death.MDM2 regulates hypoxic hypoxia-inducible factor 1α stability in an E3 ligase, proteasome, and PTEN-phosphatidylinositol 3-kinase-AKT-dependent manner.p53-Dependent and p53-independent induction of insulin-like growth factor binding protein-3 by deoxyribonucleic acid damage and hypoxia.Inhibition of endothelial cell proliferation and tumor angiogenesis by up-regulating NDRG2 expression in breast cancer cells.Oxidative toxicity in neurodegenerative diseases: role of mitochondrial dysfunction and therapeutic strategies.Up-regulation of hypoxia inducible factor-1α by cobalt chloride correlates with proliferation and apoptosis in PC-2 cells.Targeted genes and interacting proteins of hypoxia inducible factor-1.Reciprocal influence of the p53 and the hypoxic pathways Up-regulation of pVHL along with down-regulation of HIF-1α by NDRG2 expression attenuates proliferation and invasion in renal cancer cells HIF-1α and HIF-2α: siblings in promoting angiogenesis of residual hepatocellular carcinoma after high-intensity focused ultrasound ablation.Computational analysis of signaling patterns in single cells.Improved diabetic wound healing through topical silencing of p53 is associated with augmented vasculogenic mediators Hypoxia, stem cells and bone tumor Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction.Hypoxia-inducible factor-1 and oncogenic signalling.Dietary compounds galangin and myricetin suppress ovarian cancer cell angiogenesis.Genetic Variations in the TP53 Pathway in Native Americans Strongly Suggest Adaptation to the High Altitudes of the Andes.The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis Properties of switch-like bioregulatory networks studied by simulation of the hypoxia response control system.HIF-1 and p53: communication of transcription factors under hypoxia.Modeling the interplay between the HIF-1 and p53 pathways in hypoxia Hypoxia inducible factor (HIF) in rheumatology: low O2! See what HIF can do!Metabolic stress in autophagy and cell death pathways Transcriptional and Post-Transcriptional Regulation of Thrombospondin-1 Expression: A Computational Model.Metabolic regulation of oxygen and redox homeostasis by p53: lessons from evolutionary biology?Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells Pharmacologic activation of p53 by small-molecule MDM2 antagonists DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX.

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P2860

Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function

http://www.wikidata.org/entity/Q28212296

description

2003 nî lūn-bûn

@nan

2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2003年の論文

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2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

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2003年论文

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name

Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function

@ast

Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function

@en

Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function

@nl

type

label

Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function

@ast

Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function

@en

Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function

@nl

prefLabel

Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function

@ast

Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function

@en

Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function

@nl

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Journal of Biological Chemistry

P1476

Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function

@en

P2093

Delin Chen

http://www.w3.org/2001/XMLSchema#string

Jianyuan Luo

http://www.w3.org/2001/XMLSchema#string

Muyang Li

http://www.w3.org/2001/XMLSchema#string

Wei Gu

http://www.w3.org/2001/XMLSchema#string

P2860

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

A conserved family of prolyl-4-hydroxylases that modify HIF

Synergistic activation of transcription by CBP and p53

Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53.

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

Surfing the p53 network

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

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13595-8

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scholarly article

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10.1074/JBC.C200694200

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16

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278

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2003-04-18T00:00:00Z

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12606552

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