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A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385Oxidation of 4-chlorobiphenyl metabolites to electrophilic species by prostaglandin H synthaseStructural basis for certain naturally occurring bioflavonoids to function as reducing co-substrates of cyclooxygenase I and IIThe bitter barricading of prostaglandin biosynthesis pathway: understanding the molecular mechanism of selective cyclooxygenase-2 inhibition by amarogentin, a secoiridoid glycoside from Swertia chirayita.Computational Structure-Based De Novo Design of Hypothetical Inhibitors against the Anti- Inflammatory Target COX-2Myricetin and quercetin are naturally occurring co-substrates of cyclooxygenases in vivo.Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agentsPhysical evidence for substrate binding in preventing cyclooxygenase inactivation under nitrative stress.Regulation of inflammation by selenium and selenoproteins: impact on eicosanoid biosynthesis.Heme enzyme structure and function.The Effect of Cadmium on COX-1 and COX-2 Gene, Protein Expression, and Enzymatic Activity in THP-1 Macrophages.A computational protocol for the integration of the monotopic protein prostaglandin H2 synthase into a phospholipid bilayerCyclooxygenase 2 selective inhibitors in cancer treatment and prevention.Synthesis and evaluation of transthyretin amyloidosis inhibitors containing carborane pharmacophores.Acetyl Eburicoic Acid from Laetiporus sulphureus var. miniatus Suppresses Inflammation in Murine Macrophage RAW 264.7 Cells.Finasteride Enhances the Generation of Human Myeloid-Derived Suppressor Cells by Up-Regulating the COX2/PGE2 PathwayThe Chemistry and Biology of Nakiterpiosin - C-nor-D-Homosteroids.PET imaging of cyclooxygenase-2 (COX-2) in a pre-clinical colorectal cancer model.Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases.The influence of double bond geometry in the inhibition of cyclooxygenases by sulindac derivativesProstaglandin H synthase: resolved and unresolved mechanistic issues.Cyclooxygenase-2 inhibitors: a literature and patent review (2009 - 2010).Selective COX-2 Inhibitors: A Review of Their Structure-Activity Relationships.On the relationships of substrate orientation, hydrogen abstraction, and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and its Ala542Gly mutant.Cyclooxygenase-2 Mediated Oxidation of 2-Arachidonoyl-Lysophospholipids Identifies Unknown Lipid Signaling Pathways.The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancerDirect Sequencing of Cyclooxygenase-2 (COX-2) Revealed an Intronic Variant rs201231411 in Iranian Patients with Pancreatic Cancer.Paulistine--The Functional Duality of a Wasp Venom Peptide Toxin.Negative regulatory roles of ORMDL3 in the FcεRI-triggered expression of proinflammatory mediators and chemotactic response in murine mast cells.3-D structural interactions and quantitative structural toxicity studies of tyrosine derivatives intended for safe potent inflammation treatment.The Molecular Basis for Dual Fatty Acid Amide Hydrolase (FAAH)/Cyclooxygenase (COX) Inhibition.Strong activation of cyclooxygenase I and II catalytic activity by dietary bioflavonoids.Immunomodulatory effects of 17-O-acetylacuminolide in RAW264.7 cells and HUVECs: involvement of MAPK and NF-κB pathways.Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitorDetergents profoundly affect inhibitor potencies against both cyclo-oxygenase isoforms.Mass spectrometric analysis of leukotriene A4 and other chemically reactive metabolites of arachidonic acid.Maturation depresses mouse cerebrovascular tone through endothelium-dependent mechanisms.Novel selective inhibitors of hydroxyxanthone derivatives for human cyclooxygenase-2.Structural Probing, Screening and Structure-Based Drug Repositioning Insights into the Identification of Potential Cox-2 Inhibitors from Selective Coxibs.APOL1 renal risk variants induce aberrant THP-1 monocyte differentiation and increase eicosanoid production via enhanced expression of cyclooxygenase 2.
P2860
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P2860
description
2001 nî lūn-bûn
@nan
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Cyclooxygenase enzymes: catalysis and inhibition
@ast
Cyclooxygenase enzymes: catalysis and inhibition
@en
Cyclooxygenase enzymes: catalysis and inhibition
@nl
type
label
Cyclooxygenase enzymes: catalysis and inhibition
@ast
Cyclooxygenase enzymes: catalysis and inhibition
@en
Cyclooxygenase enzymes: catalysis and inhibition
@nl
prefLabel
Cyclooxygenase enzymes: catalysis and inhibition
@ast
Cyclooxygenase enzymes: catalysis and inhibition
@en
Cyclooxygenase enzymes: catalysis and inhibition
@nl
P3181
P1476
Cyclooxygenase enzymes: catalysis and inhibition
@en
P2093
L J Marnett
R G Kurumbail
P304
P3181
P356
10.1016/S0959-440X(01)00277-9
P407
P577
2001-12-01T00:00:00Z