RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?
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Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitmentHGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathwayRGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domainIdentification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeletonGalphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domainThe nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activityPlatelet signalingStructural Determinants of G-protein Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2)Insights into the molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF.Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factorRGS16 inhibits signalling through the G alpha 13-Rho axisRegulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinaseStructural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factorSemaphorin 4D signaling requires the recruitment of phospholipase C gamma into the plexin-B1 receptor complex.p63RhoGEF couples Gα(q/11)-mediated signaling to Ca2+ sensitization of vascular smooth muscle contractility.A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cellsKinetics of recruitment and allosteric activation of ARHGEF25 isoforms by the heterotrimeric G-protein GαqNon-canonical functions of RGS proteinsLysophosphatidic acid receptor 5 inhibits B cell antigen receptor signaling and antibody responseThe IκB kinase complex is required for plexin-B-mediated activation of RhoARegulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets.The Lbc Rho guanine nucleotide exchange factor α-catulin axis functions in serotonin-induced vascular smooth muscle cell mitogenesis and RhoA/ROCK activation.Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA.P-REX2, a novel PI-3-kinase sensitive Rac exchange factor.Bridging with GAPs: receptor communication through RGS proteins.Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt.Heterotrimeric G-protein alpha-12 (Gα12) subunit promotes oral cancer metastasis.Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis.Rho-kinase mediates diphosphorylation of myosin regulatory light chain in cultured uterine, but not vascular smooth muscle cells.Targeted deletion of one or two copies of the G protein β subunit Gβ5 gene has distinct effects on body weight and behavior in mice.Rac inhibits thrombin-induced Rho activation: evidence of a Pak-dependent GTPase crosstalkRgs1 regulates multiple Galpha subunits in Magnaporthe pathogenesis, asexual growth and thigmotropism.Role of Galpha12 and Galpha13 as novel switches for the activity of Nrf2, a key antioxidative transcription factor.Comparative pharmacological analysis of Rho-kinase inhibitors and identification of molecular components of Ca2+ sensitization in the rat lower urinary tract.A Model for Direction Sensing in Dictyostelium discoideum: Ras Activity and Symmetry Breaking Driven by a Gβγ-Mediated, Gα2-Ric8 -- Dependent Signal Transduction Network.Sickling cells, cyclic nucleotides, and protein kinases: the pathophysiology of urogenital disorders in sickle cell anemia.G-protein signaling: back to the futureLow expression of GNAI3 predicts poor prognosis in patients with HCC.Is caveolin-1 a viable therapeutic target to reduce cancer metastasis?Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors
P2860
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P2860
RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?
@ast
RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?
@en
RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?
@nl
type
label
RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?
@ast
RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?
@en
RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?
@nl
prefLabel
RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?
@ast
RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?
@en
RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?
@nl
P3181
P356
P1433
P1476
RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?
@en
P2093
P2888
P304
P3181
P356
10.1038/SJ.ONC.1204182
P407
P577
2001-03-01T00:00:00Z
P5875
P6179
1009959320