P-REX2, a novel PI-3-kinase sensitive Rac exchange factor.
about
Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2aRho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and diseaseRegulation and function of P-Rex family Rac-GEFsP-Rex2 regulates Purkinje cell dendrite morphology and motor coordination.Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasisPhosphorylation of P-Rex1 by the cyclic AMP-dependent protein kinase inhibits the phosphatidylinositiol (3,4,5)-trisphosphate and Gbetagamma-mediated regulation of its activity.Differential sensitivity of P-Rex1 to isoforms of G protein betagamma dimers.Identification and characterization of cancer mutations in Japanese lung adenocarcinoma without sequencing of normal tissue counterpartsSubstrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2.Novel insights into G protein and G protein-coupled receptor signaling in cancerStructure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors.Regulated localization is sufficient for hormonal control of regulator of G protein signaling homology Rho guanine nucleotide exchange factors (RH-RhoGEFs).Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits.The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4.Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase.Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42.Lack of a significant role of P-Rex1, a major regulator of macrophage Rac1 activation and chemotaxis, in atherogenesisRac signaling in breast cancer: a tale of GEFs and GAPs.p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase.Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.G protein-coupled receptor-promoted trafficking of Gbeta1gamma2 leads to AKT activation at endosomes via a mechanism mediated by Gbeta1gamma2-Rab11a interactionUpregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis.Differential inhibitor of Gbetagamma signaling to AKT and ERK derived from phosducin-like protein: effect on sphingosine 1-phosphate-induced endothelial cell migration and in vitro angiogenesismTORC1- and mTORC2-interacting proteins keep their multifunctional partners focused.RhoGEFs in cell motility: novel links between Rgnef and focal adhesion kinase.Analysis of intracellular PTEN signaling and secretion.PREX2 promotes the proliferation, invasion and migration of pancreatic cancer cells by modulating the PI3K signaling pathway.Signals and Receptors.Molecular Pathways: Targeting the PI3K Pathway in Cancer-BET Inhibitors to the RescueGβγ Pathways in Cell Polarity and Migration Linked to Oncogenic GPCR Signaling: Potential Relevance in Tumor Microenvironment.The effect of CXCL9 on the invasion ability of hepatocellular carcinoma through up-regulation of PREX2.PREX1 Protein Function Is Negatively Regulated Downstream of Receptor Tyrosine Kinase Activation by p21-activated Kinases (PAKs).Characterization of the GNMT-HectH9-PREX2 tripartite relationship in the pathogenesis of hepatocellular carcinoma.Gene polymorphisms and oral cancer risk in tobacco habitués.Multisite phosphorylation of P-Rex1 by protein kinase C.The guanine-nucleotide-exchange factor P-Rex1 is activated by protein phosphatase 1α.P-Rex2, a Rac-guanine nucleotide exchange factor, is expressed selectively in ribbon synaptic terminals of the mouse retina.P-Rex1 participates in Neuregulin-ErbB signal transduction and its expression correlates with patient outcome in breast cancer.
P2860
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P2860
P-REX2, a novel PI-3-kinase sensitive Rac exchange factor.
description
2004 nî lūn-bûn
@nan
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
P-REX2, a novel PI-3-kinase sensitive Rac exchange factor.
@ast
P-REX2, a novel PI-3-kinase sensitive Rac exchange factor.
@en
P-REX2, a novel PI-3-kinase sensitive Rac exchange factor.
@nl
type
label
P-REX2, a novel PI-3-kinase sensitive Rac exchange factor.
@ast
P-REX2, a novel PI-3-kinase sensitive Rac exchange factor.
@en
P-REX2, a novel PI-3-kinase sensitive Rac exchange factor.
@nl
prefLabel
P-REX2, a novel PI-3-kinase sensitive Rac exchange factor.
@ast
P-REX2, a novel PI-3-kinase sensitive Rac exchange factor.
@en
P-REX2, a novel PI-3-kinase sensitive Rac exchange factor.
@nl
P2860
P1433
P1476
P-REX2, a novel PI-3-kinase sensitive Rac exchange factor
@en
P2093
Hans Rosenfeldt
P2860
P304
P356
10.1016/J.FEBSLET.2004.06.097
P407
P577
2004-08-01T00:00:00Z