Development of a high-throughput fluorescence polarization assay for Bcl-x(L)
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Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer TherapyStructure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2Determinants of BH3 Binding Specificity for Mcl-1 versus Bcl-xLABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing plateletsAn inhibitor of Bcl-2 family proteins induces regression of solid tumoursDirect Activation of Bax Protein for Cancer TherapyStructure-based redesign of the binding specificity of anti-apoptotic Bcl-x(L).A luciferase based viability assay for ATP detection in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427.Heterocyclic alpha-helix mimetics for targeting protein-protein interactionsHigh-throughput screen for the chemical inhibitors of antiapoptotic bcl-2 family proteins by multiplex flow cytometry.Small-molecule Bax agonists for cancer therapy.Enhanced metabolic stability and protein-binding properties of artificial alpha helices derived from a hydrogen-bond surrogate: application to Bcl-xL.Novel small-molecule inhibitors of Bcl-XL to treat lung cancer.Towards more drug-like proteomimetics: two-faced, synthetic α-helix mimetics based on a purine scaffold.Biochemical and biophysical investigations of the interaction between human glucokinase and pro-apoptotic BAD.Structure-based design of N-substituted 1-hydroxy-4-sulfamoyl-2-naphthoates as selective inhibitors of the Mcl-1 oncoprotein.Defining specificity and on-target activity of BH3-mimetics using engineered B-ALL cell lines.Discovery of ABT-263, a Bcl-family protein inhibitor: observations on targeting a large protein-protein interaction.Recapitulating the α-helix: nonpeptidic, low-molecular-weight ligands for the modulation of helix-mediated protein-protein interactions.Oral disinfectants inhibit protein-protein interactions mediated by the anti-apoptotic protein Bcl-xL and induce apoptosis in human oral tumor cells.Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors.Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.Modeling backbone flexibility to achieve sequence diversity: the design of novel alpha-helical ligands for Bcl-xL.A fluorescence polarization assay for identifying ligands that bind to vascular endothelial growth factor.Dynamical binding of hydrogen-bond surrogate derived Bak helices to antiapoptotic protein Bcl-xL.Characterization of the anti-apoptotic mechanism of Bcl-BAnti-cancer drug discovery and development: Bcl-2 family small molecule inhibitors.Downsizing the BAD BH3 peptide to small constrained α-helices with improved ligand efficiency.Modulation of Bax and mTOR for Cancer Therapeutics.Direct monitoring of protein–protein inhibition using nano electrospray ionization mass spectrometry
P2860
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P2860
Development of a high-throughput fluorescence polarization assay for Bcl-x(L)
description
2002 nî lūn-bûn
@nan
2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Development of a high-throughput fluorescence polarization assay for Bcl-x(L)
@ast
Development of a high-throughput fluorescence polarization assay for Bcl-x(L)
@en
Development of a high-throughput fluorescence polarization assay for Bcl-x(L)
@nl
type
label
Development of a high-throughput fluorescence polarization assay for Bcl-x(L)
@ast
Development of a high-throughput fluorescence polarization assay for Bcl-x(L)
@en
Development of a high-throughput fluorescence polarization assay for Bcl-x(L)
@nl
prefLabel
Development of a high-throughput fluorescence polarization assay for Bcl-x(L)
@ast
Development of a high-throughput fluorescence polarization assay for Bcl-x(L)
@en
Development of a high-throughput fluorescence polarization assay for Bcl-x(L)
@nl
P2093
P1476
Development of a high-throughput fluorescence polarization assay for Bcl-x(L)
@en
P2093
Haichao Zhang
Mary Joseph
Paul Nimmer
Saul H Rosenberg
Shi-Chung Ng
P356
10.1016/S0003-2697(02)00028-3
P407
P577
2002-08-01T00:00:00Z