Enhanced metabolic stability and protein-binding properties of artificial alpha helices derived from a hydrogen-bond surrogate: application to Bcl-xL.
about
All-atom model for stabilization of alpha-helical structure in peptides by hydrocarbon staples.Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based DesignRational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 InhibitorsEvaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 DomainThe paradox of conformational constraint in the design of Cbl(TKB)-binding peptidesStructure-Guided Rational Design of α/β-Peptide Foldamers with High Affinity for BCL-2 Family Prosurvival ProteinsApplication of ring-closing metathesis to Grb2 SH3 domain-binding peptides.Constraining cyclic peptides to mimic protein structure motifs.Truncated and helix-constrained peptides with high affinity and specificity for the cFos coiled-coil of AP-1A cell-penetrating helical peptide as a potential HIV-1 inhibitor.Contemporary strategies for the stabilization of peptides in the alpha-helical conformation.Application of ring-closing metathesis macrocyclization to the development of Tsg101-binding antagonists.Novel pyrrolopyrimidine-based α-helix mimetics: cell-permeable inhibitors of protein−protein interactionsUniversal peptidomimetics.Minimalist and universal peptidomimetics.Mini review: protein-protein interactions in transcription: a fertile ground for helix mimetics.Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactionsTightening up the structure, lighting up the pathway: Application of molecular constraints and light to manipulate protein folding, self-assembly and function.Ribosomal Synthesis of Macrocyclic Peptides in Vitro and in Vivo Mediated by Genetically Encoded Aminothiol Unnatural Amino AcidsDesigner macrocyclic organo-peptide hybrids inhibit the interaction between p53 and HDM2/X by accommodating a functional α-helix.Solid-phase synthesis of short α-helices stabilized by the hydrogen bond surrogate approach.Nucleation effects in peptide foldamersDevelopment of α-helical calpain probes by mimicking a natural protein-protein interaction.Side-chain-to-tail cyclization of ribosomally derived peptides promoted by aryl and alkyl amino-functionalized unnatural amino acidsFunctional, metal-based crosslinkers for α-helix induction in short peptidesCovalent capture: merging covalent and noncovalent synthesis.Helix-mediated protein--protein interactions as targets for intervention using foldamers.Druggability assessment of protein-protein interfaces.Review backbone N-modified peptides: How to meet the challenge of secondary amine acylation.Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.Targeting recognition surfaces on natural proteins with peptidic foldamersHydrophile scanning as a complement to alanine scanning for exploring and manipulating protein-protein recognition: application to the Bim BH3 domain.α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells.Profiling small molecule inhibitors against helix-receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2.Dynamical binding of hydrogen-bond surrogate derived Bak helices to antiapoptotic protein Bcl-xL.Extending foldamer design beyond α-helix mimicry: α/β-peptide inhibitors of vascular endothelial growth factor signaling.Inhibition of hypoxia inducible factor 1-transcription coactivator interaction by a hydrogen bond surrogate alpha-helix.Sequence-based design of alpha/beta-peptide foldamers that mimic BH3 domains.High specificity in protein recognition by hydrogen-bond-surrogate α-helices: selective inhibition of the p53/MDM2 complex.Evaluation of biologically relevant short alpha-helices stabilized by a main-chain hydrogen-bond surrogate
P2860
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P2860
Enhanced metabolic stability and protein-binding properties of artificial alpha helices derived from a hydrogen-bond surrogate: application to Bcl-xL.
description
2005 nî lūn-bûn
@nan
2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Enhanced metabolic stability a ...... rogate: application to Bcl-xL.
@ast
Enhanced metabolic stability a ...... rogate: application to Bcl-xL.
@en
Enhanced metabolic stability a ...... rogate: application to Bcl-xL.
@nl
type
label
Enhanced metabolic stability a ...... rogate: application to Bcl-xL.
@ast
Enhanced metabolic stability a ...... rogate: application to Bcl-xL.
@en
Enhanced metabolic stability a ...... rogate: application to Bcl-xL.
@nl
prefLabel
Enhanced metabolic stability a ...... rogate: application to Bcl-xL.
@ast
Enhanced metabolic stability a ...... rogate: application to Bcl-xL.
@en
Enhanced metabolic stability a ...... rogate: application to Bcl-xL.
@nl
P2093
P2860
P356
P1476
Enhanced metabolic stability a ...... rogate: application to Bcl-xL.
@en
P2093
Deyun Wang
Paramjit S Arora
P2860
P304
P356
10.1002/ANIE.200501603
P407
P577
2005-10-01T00:00:00Z