Transmembrane domain I of the gamma-aminobutyric acid transporter GAT-1 plays a crucial role in the transition between cation leak and transport modes
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A steered molecular dynamics study of binding and translocation processes in the GABA transporterThe aqueous accessibility in the external half of transmembrane domain I of the GABA transporter GAT-1 Is modulated by its ligandsRole of the conserved glutamine 291 in the rat gamma-aminobutyric acid transporter rGAT-1A conserved salt bridge between transmembrane segments 1 and 10 constitutes an extracellular gate in the dopamine transporterAssessing the ability of sequence-based methods to provide functional insight within membrane integral proteins: a case study analyzing the neurotransmitter/Na+ symporter family.GABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRETMolecular modeling and ligand docking for solute carrier (SLC) transportersTransmembrane domain 6 of the human serotonin transporter contributes to an aqueously accessible binding pocket for serotonin and the psychostimulant 3,4-methylene dioxymethamphetamine.The second sodium site in the dopamine transporter controls cation permeation and is regulated by chloride.High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach.Novel properties of a mouse gamma-aminobutyric acid transporter (GAT4).Conformationally sensitive proximity of extracellular loops 2 and 4 of the γ-aminobutyric acid (GABA) transporter GAT-1 inferred from paired cysteine mutagenesisFunctional consequences of sulfhydryl modification of the γ-aminobutyric acid transporter 1 at a single solvent-exposed cysteine residue.Inhibitors of the gamma-aminobutyric acid transporter 1 (GAT1) do not reveal a channel mode of conductionAn Extra Amino Acid Residue in Transmembrane Domain 10 of the γ-Aminobutyric Acid (GABA) Transporter GAT-1 Is Required for Efficient Ion-coupled Transport.A glutamine residue conserved in the neurotransmitter:sodium:symporters is essential for the interaction of chloride with the GABA transporter GAT-1.Functional defects in the external and internal thin gates of the γ-aminobutyric acid (GABA) transporter GAT-1 can compensate each otherThe aromatic and charge pairs of the thin extracellular gate of the γ-aminobutyric acid transporter GAT-1 are differently impacted by mutationGlutamate 59 is critical for transport function of the amino acid cotransporter KAAT1.Elucidating conformational changes in the gamma-aminobutyric acid transporter-1.An acidic amino acid transmembrane helix 10 residue conserved in the neurotransmitter:sodium:symporters is essential for the formation of the extracellular gate of the γ-aminobutyric acid (GABA) transporter GAT-1.Serotonin and cocaine-sensitive inactivation of human serotonin transporters by methanethiosulfonates targeted to transmembrane domain I.Zinc potentiates an uncoupled anion conductance associated with the dopamine transporter.Revised Ion/Substrate Coupling Stoichiometry of GABA Transporters.Transporter-associated currents in the gamma-aminobutyric acid transporter GAT-1 are conditionally impaired by mutations of a conserved glycine residue.The substrates of the gamma-aminobutyric acid transporter GAT-1 induce structural rearrangements around the interface of transmembrane domains 1 and 6.Development of Non-GAT1-Selective Inhibitors: Challenges and Achievements.Threonine 67 is a key component in the coupling of the NSS amino acid transporter KAAT1.Using lithium to probe sequential cation interactions with GAT1.Lithium interactions with Na+-coupled inorganic phosphate cotransporters: insights into the mechanism of sequential cation binding.Selective amino acid substitutions convert the creatine transporter to a gamma-aminobutyric acid transporter.
P2860
Q27300859-AB7DCBFD-1B6D-4EDA-A0CB-C60DCCF33097Q28240888-14BC00C8-F2FA-44D2-BD3D-E4E5BF07ABDFQ28569505-B9CBB205-9C3B-413F-AE60-83D8E0E5A622Q30368030-DAA7B335-B6CA-4342-8DCC-FECE66C66B4CQ30481053-F9BB67F1-1912-41EA-8DDC-A22D1644A01EQ33590316-8045068E-0BBF-479E-8638-BCF52946C302Q33751096-EE476EFC-0129-48DA-90ED-46983B4497A0Q33799683-01E1B848-79A9-4981-97AD-37A26CEC502EQ34170768-1B7EB384-6054-4953-AC52-45F1D736588FQ34397703-6B4CA946-E593-4BCC-9877-4692C92E2E88Q34437574-102997C3-07B8-4E90-8FE3-8A94F36E661AQ34634301-D0547021-C0E7-4F0F-A0E8-1BF0B8BA2993Q36420798-EE3C5FBF-C4D9-4001-8000-FD16D21C92F9Q37394134-B9901816-02C0-4F2B-A2F7-073819DAB8E1Q38954548-9C5025D4-4AB6-4A52-8871-BDC0DF5C8B1CQ41814906-88415FF8-FF84-47AA-A3EB-DFEC3D7E45E9Q41874560-E11DC5EE-6A54-43DC-A2A7-4586B8C68DC9Q42020176-FD85677B-63C5-4E8D-8E73-1E037E016146Q42048148-6C04BB7E-8598-4C5B-94AE-4D6F4B28C178Q42554749-66CF8D08-57B5-4BBA-A7FB-5ECE56DDA831Q42605543-8788BFC1-B685-4015-BE45-F975178A6C15Q44517534-2933A14D-F6ED-4D18-9968-903C25119D86Q45052903-1A62FB69-CBB0-46B1-A89A-15DB949DCD82Q46111785-F9ED60BD-1327-466C-BDC8-B0154E77CF86Q46398280-58C5AA4D-6542-4785-94F7-AA0AC87FD0E9Q46670235-33072DA0-02FF-4125-AA19-180DA769A89EQ48144959-571AC37F-A37D-437D-AFF1-5618EDBCCE5DQ48501818-C6FE508E-987E-4FAD-BC17-3213FC8D96CFQ48652068-CCF979B8-05AA-4227-831D-7DBEF541CB7CQ48661752-5C35B521-29B8-49EF-B509-A5C69C9BD723Q51990209-D6596D84-9EA4-4DBA-9FE0-70145F8C0EEC
P2860
Transmembrane domain I of the gamma-aminobutyric acid transporter GAT-1 plays a crucial role in the transition between cation leak and transport modes
description
2003 nî lūn-bûn
@nan
2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Transmembrane domain I of the ...... ation leak and transport modes
@ast
Transmembrane domain I of the ...... ation leak and transport modes
@en
Transmembrane domain I of the ...... ation leak and transport modes
@nl
type
label
Transmembrane domain I of the ...... ation leak and transport modes
@ast
Transmembrane domain I of the ...... ation leak and transport modes
@en
Transmembrane domain I of the ...... ation leak and transport modes
@nl
prefLabel
Transmembrane domain I of the ...... ation leak and transport modes
@ast
Transmembrane domain I of the ...... ation leak and transport modes
@en
Transmembrane domain I of the ...... ation leak and transport modes
@nl
P2860
P356
P1476
Transmembrane domain I of the ...... ation leak and transport modes
@en
P2093
Baruch I Kanner
P2860
P304
P356
10.1074/JBC.M210525200
P407
P577
2003-02-07T00:00:00Z