NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways
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Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombinationMdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retentionA PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replicationRecruitment and activation of the ATM kinase in the absence of DNA-damage sensors.Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domainDimerization, but not phosphothreonine binding, is conserved between the forkhead-associated domains of Drosophila MU2 and human MDC1NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damagePhosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domainsMediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint controlThe DNA damage response mediator MDC1 directly interacts with the anaphase-promoting complex/cyclosomeCell-cycle checkpoints and cancerNFBD1/MDC1 associates with p53 and regulates its function at the crossroad between cell survival and death in response to DNA damageSite-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1Differential regulation of centrosome integrity by DNA damage response proteins.Mediator of DNA damage checkpoint 1 (MDC1) contributes to high NaCl-induced activation of the osmoprotective transcription factor TonEBP/OREBP.BCL10 regulates RNF8/RNF168-mediated ubiquitination in the DNA damage response.Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage.Recruitment kinetics of DNA repair proteins Mdc1 and Rad52 but not 53BP1 depend on damage complexity.MDC1 interacts with Rad51 and facilitates homologous recombination.HERC2/USP20 coordinates CHK1 activation by modulating CLASPIN stabilityNFBD1/MDC1 is phosphorylated by PLK1 and controls G2/M transition through the regulation of a TOPOIIα-mediated decatenation checkpointHistone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeastDNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cellsModulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damageChecking on DNA damage in S phase.Histone ubiquitination and deubiquitination in transcription, DNA damage response, and cancer.Molecular basis of ataxia telangiectasia and related diseases.Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks.Candidate protein biodosimeters of human exposure to ionizing radiation.The DNA damage response pathways: at the crossroad of protein modifications.BRCA1 and its toolbox for the maintenance of genome integrityAssembly of checkpoint and repair machineries at DNA damage sites.Phosphorylation of LSD1 by PLK1 promotes its chromatin release during mitosis.Interplay between the DNA damage proteins MDC1 and ATM in the regulation of the spindle assembly checkpoint.Mycobacterium tuberculosis universal stress protein Rv2623 interacts with the putative ATP binding cassette (ABC) transporter Rv1747 to regulate mycobacterial growth.NFBD1/MDC1 regulates Cav1 and Cav2 independently of DNA damage and p53.DNA damage signaling in response to double-strand breaks during mitosis.Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability.Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition.
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NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways
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2003 nî lūn-bûn
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2003年の論文
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NFBD1/KIAA0170 is a chromatin- ...... DNA damage signaling pathways
@ast
NFBD1/KIAA0170 is a chromatin- ...... DNA damage signaling pathways
@en
NFBD1/KIAA0170 is a chromatin- ...... DNA damage signaling pathways
@nl
type
label
NFBD1/KIAA0170 is a chromatin- ...... DNA damage signaling pathways
@ast
NFBD1/KIAA0170 is a chromatin- ...... DNA damage signaling pathways
@en
NFBD1/KIAA0170 is a chromatin- ...... DNA damage signaling pathways
@nl
prefLabel
NFBD1/KIAA0170 is a chromatin- ...... DNA damage signaling pathways
@ast
NFBD1/KIAA0170 is a chromatin- ...... DNA damage signaling pathways
@en
NFBD1/KIAA0170 is a chromatin- ...... DNA damage signaling pathways
@nl
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NFBD1/KIAA0170 is a chromatin- ...... DNA damage signaling pathways
@en
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David F Stern
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10.1074/JBC.M211392200
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P50
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2002-12-23T00:00:00Z