Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II
about
Rad GTPase deficiency leads to cardiac hypertrophyPhosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activityEffects of phosphorylation on function of the Rad GTPaseRegulation of voltage-gated calcium channel activity by the Rem and Rad GTPasesThe GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathwayInteraction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulationExpression, purification, crystallization and preliminary crystallographic analysis of human Rad GTPaseActivity-dependent subcellular cotrafficking of the small GTPase Rem2 and Ca2+/CaM-dependent protein kinase IIαStructure of the GDP-bound G domain of the RGK protein Rem2IQGAP1 and calmodulin modulate E-cadherin functionCa2+/calmodulin stimulates GTP binding to the ras-related protein ral-AThe ß subunit of voltage-gated Ca2+ channelsThe role of G proteins in insulin signalling.Both the C-terminal polylysine region and the farnesylation of K-RasB are important for its specific interaction with calmodulinUnexpected cross talk: small GTPase regulation of calcium channel trafficking.Crystal structure of human Rad GTPase of the RGK-family.Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level.Plasma membrane targeting is essential for Rem-mediated Ca2+ channel inhibition.IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.Molecular determinants of Gem protein inhibition of P/Q-type Ca2+ channelsGes, A human GTPase of the Rad/Gem/Kir family, promotes endothelial cell sprouting and cytoskeleton reorganization.Identification of novel light-induced genes in the suprachiasmatic nucleusThe RGK family of GTP-binding proteins: regulators of voltage-dependent calcium channels and cytoskeleton remodeling.Rad GTPase inhibits cardiac fibrosis through connective tissue growth factorCaMKII-dependent phosphorylation of the GTPase Rem2 is required to restrict dendritic complexity.Diminished skeletal muscle microRNA expression with aging is associated with attenuated muscle plasticity and inhibition of IGF-1 signaling.Regulation of voltage-dependent calcium channels by RGK proteins.RGK regulation of voltage-gated calcium channels.Rad is temporally regulated within myogenic progenitor cells during skeletal muscle regeneration.RRAD inhibits the Warburg effect through negative regulation of the NF-κB signaling.Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRADThe Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9.Roles of 14-3-3 and calmodulin binding in subcellular localization and function of the small G-protein Rem2.RhoE function is regulated by ROCK I-mediated phosphorylation.Rad and Rem are non-canonical G-proteins with respect to the regulatory role of guanine nucleotide binding in Ca(V)1.2 channel regulation.Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin.Analysis of differential gene expression in colorectal cancer and stroma using fluorescence-activated cell sorting purification.Gem associates with Ezrin and acts via the Rho-GAP protein Gmip to down-regulate the Rho pathway.Neuronal survival induced by neurotrophins requires calmodulin.Validation of biomarkers for loin meat quality (M. longissimus) of pigs.
P2860
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P2860
Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II
description
1997 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1997
@ast
im Mai 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 2 May 1997)
@en
vedecký článok (publikovaný 1997/05/02)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/05/02)
@nl
наукова стаття, опублікована в травні 1997
@uk
name
Rad and Rad-related GTPases in ...... in-dependent protein kinase II
@ast
Rad and Rad-related GTPases in ...... in-dependent protein kinase II
@en
Rad and Rad-related GTPases in ...... in-dependent protein kinase II
@nl
type
label
Rad and Rad-related GTPases in ...... in-dependent protein kinase II
@ast
Rad and Rad-related GTPases in ...... in-dependent protein kinase II
@en
Rad and Rad-related GTPases in ...... in-dependent protein kinase II
@nl
prefLabel
Rad and Rad-related GTPases in ...... in-dependent protein kinase II
@ast
Rad and Rad-related GTPases in ...... in-dependent protein kinase II
@en
Rad and Rad-related GTPases in ...... in-dependent protein kinase II
@nl
P2093
P356
P1476
Rad and Rad-related GTPases in ...... in-dependent protein kinase II
@en
P2093
P304
P356
10.1074/JBC.272.18.11832
P407
P577
1997-05-02T00:00:00Z