53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage
about
ATM-dependent phosphorylation of ATF2 is required for the DNA damage responseThe cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cellsVaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damageFunctional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppressionHuman Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpointMdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retentionImmunoglobulin class switch recombination is impaired in Atm-deficient miceFunctional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrestMre11 assembles linear DNA fragments into DNA damage signaling complexesDNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of CancerDistinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesisA mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpointDNA IR-Double Strand Breaks (DSBs) and cellular response via ATMDifferential regulation of centrosome integrity by DNA damage response proteins.Mediator of DNA damage checkpoint 1 (MDC1) contributes to high NaCl-induced activation of the osmoprotective transcription factor TonEBP/OREBP.ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.Regulation of the DNA Damage Response to DSBs by Post-Translational Modifications.Productive replication of human papillomavirus 31 requires DNA repair factor Nbs1.The versatile functions of ATM kinase.A plausible model for the digital response of p53 to DNA damage.The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint.53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis.BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability.Ruta graveolens extract induces DNA damage pathways and blocks Akt activation to inhibit cancer cell proliferation and survivalTying the loose ends together in DNA double strand break repair with 53BP1.Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1.Significance of p53-binding protein 1 nuclear foci in uterine cervical lesions: endogenous DNA double strand breaks and genomic instability during carcinogenesisWilms' tumor 1 silencing decreases the viability and chemoresistance of glioblastoma cells in vitro: a potential role for IGF-1R de-repressionRIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signalingDistinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosisDynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1USP-11 as a predictive and prognostic factor following neoadjuvant therapy in women with breast cancer53BP1 suppresses tumor growth and promotes susceptibility to apoptosis of ovarian cancer cells through modulation of the Akt pathwayGenetic polymorphisms and cervical cancer development: ATM G5557A and p53bp1 C1236G.Non-problematic risks from low-dose radiation-induced DNA damage clustersMEK inhibitor GSK1120212-mediated radiosensitization of pancreatic cancer cells involves inhibition of DNA double-strand break repair pathways.Nbs1-dependent binding of Mre11 to adenovirus E4 mutant viral DNA is important for inhibiting DNA replication.PTIP regulates 53BP1 and SMC1 at the DNA damage sitesTaking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response.
P2860
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P2860
53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage
description
2003 nî lūn-bûn
@nan
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
53BP1 and NFBD1/MDC1-Nbs1 func ...... ATM) in response to DNA damage
@ast
53BP1 and NFBD1/MDC1-Nbs1 func ...... ATM) in response to DNA damage
@en
53BP1 and NFBD1/MDC1-Nbs1 func ...... ATM) in response to DNA damage
@nl
type
label
53BP1 and NFBD1/MDC1-Nbs1 func ...... ATM) in response to DNA damage
@ast
53BP1 and NFBD1/MDC1-Nbs1 func ...... ATM) in response to DNA damage
@en
53BP1 and NFBD1/MDC1-Nbs1 func ...... ATM) in response to DNA damage
@nl
prefLabel
53BP1 and NFBD1/MDC1-Nbs1 func ...... ATM) in response to DNA damage
@ast
53BP1 and NFBD1/MDC1-Nbs1 func ...... ATM) in response to DNA damage
@en
53BP1 and NFBD1/MDC1-Nbs1 func ...... ATM) in response to DNA damage
@nl
P2093
P1433
P1476
53BP1 and NFBD1/MDC1-Nbs1 func ...... ATM) in response to DNA damage
@en
P2093
Monica Venere
Richard A DiTullio
Tamara A Mochan
Thanos D Halazonetis
P304
P407
P577
2003-12-01T00:00:00Z