ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. - Wikidata - awgldk - TriplyDB

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

http://www.wikidata.org/entity/Q33863002

about

Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication The dictyostelium kinome--analysis of the protein kinases from a simple model organism.Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication SIRT1 regulates the function of the Nijmegen breakage syndrome protein RAD50 and NBS1 form a stable complex functional in DNA binding and tethering A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1 Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications Emerging common themes in regulation of PIKKs and PI3Ks The Knowns Unknowns: Exploring the Homologous Recombination Repair Pathway in Toxoplasma gondii ATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to Adaptor Structure of a Second BRCT Domain Identified in the Nijmegen Breakage Syndrome Protein Nbs1 and its Function in an MDC1-Dependent Localization of Nbs1 to DNA Damage Sites Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair γH2A binds Brc1 to maintain genome integrity during S-phase ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage Tel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand Breaks Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study ATR: an essential regulator of genome integrity Structures of closed and open conformations of dimeric human ATM Identification of Plasmodium falciparum DNA Repair Protein Mre11 with an Evolutionarily Conserved Nuclease Function Nuclear export of NBN is required for normal cellular responses to radiation The FHA domain determines Drosophila Chk2/Mnk localization to key mitotic structures and is essential for early embryonic DNA damage responses.A novel mouse model for ataxia-telangiectasia with a N-terminal mutation displays a behavioral defect and a low incidence of lymphoma but no increased oxidative burden.The involvement of ataxia-telangiectasia mutated protein activation in nucleotide excision repair-facilitated cell survival with cisplatin treatment.Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection.The Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells.Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres.

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P2860

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

http://www.wikidata.org/entity/Q33863002

description

2005 nî lūn-bûn

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2005 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2005 թվականի հուլիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

ATM activation and its recruit ...... ing to the C terminus of Nbs1.

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ATM activation and its recruit ...... ing to the C terminus of Nbs1.

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type

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ATM activation and its recruit ...... ing to the C terminus of Nbs1.

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ATM activation and its recruit ...... ing to the C terminus of Nbs1.

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ATM activation and its recruit ...... ing to the C terminus of Nbs1.

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ATM activation and its recruit ...... ing to the C terminus of Nbs1.

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MCB.25.13.5363-5379.2005

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Molecular and Cellular Biology

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ATM activation and its recruit ...... ing to the C terminus of Nbs1.

@en

P2093

Charly Chahwan

http://www.w3.org/2001/XMLSchema#string

Julie Bailis

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Paul Russell

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Tony Hunter

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Zhongsheng You

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P2860

The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp

NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

Mapping of protein-protein interactions within the DNA-dependent protein kinase complex

Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe

Mre11 assembles linear DNA fragments into DNA damage signaling complexes

Structure of importin-beta bound to the IBB domain of importin-alpha

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5363-5379

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scholarly article

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10.1128/MCB.25.13.5363-5379.2005

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13

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15964794

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1156989

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