In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase
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2.6 Å X-ray Crystal Structure of Human p53R2, a p53-Inducible Ribonucleotide Reductase,The conserved Lys-95 charged residue cluster is critical for the homodimerization and enzyme activity of human ribonucleotide reductase small subunit M2Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA ReplicationModulating radiation resistance by inhibiting ribonucleotide reductase in cancers with virally or mutationally silenced p53 proteinPhase I trial of pelvic radiation, weekly cisplatin, and 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) for locally advanced cervical cancer.Iron and cancer: more ore to be mined.Ribonucleotide reductase metallocofactor: assembly, maintenance and inhibition.Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity.Identification and characterization of alternative promoters, transcripts and protein isoforms of zebrafish R2 gene.Mechanism of inactivation of human ribonucleotide reductase with p53R2 by gemcitabine 5'-diphosphateStable suppression of the R2 subunit of ribonucleotide reductase by R2-targeted short interference RNA sensitizes p53(-/-) HCT-116 colon cancer cells to DNA-damaging agents and ribonucleotide reductase inhibitors.A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo.Structural basis on the dityrosyl-diiron radical cluster and the functional differences of human ribonucleotide reductase small subunits hp53R2 and hRRM2.Ribonucleotide reductase small subunit M2B prognoses better survival in colorectal cancerThe Novel Ribonucleotide Reductase Inhibitor COH29 Inhibits DNA Repair In VitroProgesterone and DNA damage encourage uterine cell proliferation and decidualization through up-regulating ribonucleotide reductase 2 expression during early pregnancy in mice.Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases.p53R2 expression as a prognostic biomarker in early stage non-small cell lung cancerPYCR1 and PYCR2 Interact and Collaborate with RRM2B to Protect Cells from Overt Oxidative Stress.Human Cytomegalovirus Can Procure Deoxyribonucleotides for Viral DNA Replication in the Absence of Retinoblastoma Protein Phosphorylation.Synthetic and natural iron chelators: therapeutic potential and clinical useA heterozygous truncating mutation in RRM2B causes autosomal-dominant progressive external ophthalmoplegia with multiple mtDNA deletions.Gemcitabine and carboplatin demonstrate synergistic cytotoxicity in cervical cancer cells by inhibiting DNA synthesis and increasing cell apoptosis.Targeting ribonucleotide reductase for cancer therapy.Deoxyribonucleotide metabolism, mutagenesis and cancer.Non-enzymatic action of RRM1 protein upregulates PTEN leading to inhibition of colorectal cancer metastasis.Regulation of p53 and cell proliferation by resveratrol and its derivatives in breast cancer cells: an in silico and biochemical approach targeting integrin αvβ3.Proton Coupled Electron Transfer and Redox Active Tyrosines: Structure and Function of the Tyrosyl Radicals in Ribonucleotide Reductase and Photosystem II.Determination of the in vivo stoichiometry of tyrosyl radical per betabeta' in Saccharomyces cerevisiae ribonucleotide reductase.RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)[Ribonucleotide reductase and non-small cell lung cancer].
P2860
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P2860
In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
In vitro characterization of e ...... human ribonucleotide reductase
@ast
In vitro characterization of e ...... human ribonucleotide reductase
@en
In vitro characterization of e ...... human ribonucleotide reductase
@nl
type
label
In vitro characterization of e ...... human ribonucleotide reductase
@ast
In vitro characterization of e ...... human ribonucleotide reductase
@en
In vitro characterization of e ...... human ribonucleotide reductase
@nl
prefLabel
In vitro characterization of e ...... human ribonucleotide reductase
@ast
In vitro characterization of e ...... human ribonucleotide reductase
@en
In vitro characterization of e ...... human ribonucleotide reductase
@nl
P2093
P1433
P1476
In vitro characterization of e ...... human ribonucleotide reductase
@en
P2093
Bingsen Zhou
Jimin Shao
Weihua Qiu
Yate-Ching Yuan
P356
10.1158/0008-5472.CAN-03-3048
P407
P577
2004-01-01T00:00:00Z