p53 mutations in benzo(a)pyrene-exposed human p53 knock-in murine fibroblasts correlate with p53 mutations in human lung tumors
about
Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking waterModelling mutational landscapes of human cancers in vitro.CSF1 is a novel p53 target gene whose protein product functions in a feed-forward manner to suppress apoptosis and enhance p53-mediated growth arrest.Applications of the human p53 knock-in (Hupki) mouse model for human carcinogen testing.Benzo[a]pyrene, aflatoxine B₁ and acetaldehyde mutational patterns in TP53 gene using a functional assay: relevance to human cancer aetiologyUnveiling the methylation status of CpG dinucleotides in the substituted segment of the human p53 knock-in (Hupki) mouse genome.Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression.Crippling p53 activities via knock-in mutations in mouse models.TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts.Na,K-ATPase is a target of cigarette smoke and reduced expression predicts poor patient outcome of smokers with lung cancerQuantitation of N-acetyl-S-(9,10-dihydro-9-hydroxy-10-phenanthryl)-L-cysteine in human urine: comparison with glutathione-S-transferase genotypes in smokers.Second-hand smoke and human lung cancerMutational spectra of human cancer.How to become immortal: let MEFs count the waysEvaluation of in vivo mutagenesis for assessing the health risk of air pollutants.Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model.Insights into wild-type and mutant p53 functions provided by genetically engineered mice.Modeling cancer driver events in vitro using barrier bypass-clonal expansion assays and massively parallel sequencing.Nutlin-3a selects for cells harbouring TP53 mutations.The genome as a record of environmental exposureModelling Mutation Spectra of Human Carcinogens Using Experimental Systems.Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells.Wild-type and Hupki (human p53 knock-in) murine embryonic fibroblasts: p53/ARF pathway disruption in spontaneous escape from senescence.Comparison of the metabolic activation of environmental carcinogens in mouse embryonic stem cells and mouse embryonic fibroblasts.Frequency and spectrum of lacI mutations in the liver of Big Blue mice following the administration of genotoxic carcinogens singly and in series.
P2860
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P2860
p53 mutations in benzo(a)pyrene-exposed human p53 knock-in murine fibroblasts correlate with p53 mutations in human lung tumors
description
2005 nî lūn-bûn
@nan
2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
p53 mutations in benzo(a)pyren ...... mutations in human lung tumors
@ast
p53 mutations in benzo(a)pyren ...... mutations in human lung tumors
@en
p53 mutations in benzo(a)pyren ...... mutations in human lung tumors
@nl
type
label
p53 mutations in benzo(a)pyren ...... mutations in human lung tumors
@ast
p53 mutations in benzo(a)pyren ...... mutations in human lung tumors
@en
p53 mutations in benzo(a)pyren ...... mutations in human lung tumors
@nl
prefLabel
p53 mutations in benzo(a)pyren ...... mutations in human lung tumors
@ast
p53 mutations in benzo(a)pyren ...... mutations in human lung tumors
@en
p53 mutations in benzo(a)pyren ...... mutations in human lung tumors
@nl
P2093
P1433
P1476
p53 mutations in benzo(a)pyren ...... mutations in human lung tumors
@en
P2093
Djeda Belharazem
Heinz H Schmeiser
Karl-Rudolf Muehlbauer
Manfred Hergenhahn
Monica C Hollstein
Zhipei Liu
P304
P356
10.1158/0008-5472.CAN-04-3675
P407
P577
2005-04-01T00:00:00Z