A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion
about
Complexin activates exocytosis of distinct secretory vesicles controlled by different synaptotagminsComplexins: small but capableDistinct initial SNARE configurations underlying the diversity of exocytosisA Chemical Controller of SNARE-Driven Membrane Fusion That Primes Vesicles for Ca(2+)-Triggered Millisecond ExocytosisComplexin cross-links prefusion SNAREs into a zigzag arrayComplexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activitySynaptic vesicles position complexin to block spontaneous fusionRing-like oligomers of Synaptotagmins and related C2 domain proteinsComplexin 3 Increases the Fidelity of Signaling in a Retinal Circuit by Regulating Exocytosis at Ribbon Synapses.Dilation of fusion pores by crowding of SNARE proteinsRe-examining how complexin inhibits neurotransmitter release.Crystallization and preliminary X-ray diffraction analysis of Gos1p, a yeast SNARE proteinHow could SNARE proteins open a fusion pore?Genetic analysis of the Complexin trans-clamping model for cross-linking SNARE complexes in vivoComplexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanismsTensor-based morphometry and stereology reveal brain pathology in the complexin1 knockout mouseInvolvement of complexin 2 in docking, locking and unlocking of different SNARE complexes during sperm capacitation and induced acrosomal exocytosis.The SNARE complex in neuronal and sensory cells.Membrane curvature sensing by the C-terminal domain of complexin.Calcium sensitive ring-like oligomers formed by synaptotagminThe accessory helix of complexin functions by stabilizing central helix secondary structureA sequential vesicle pool model with a single release sensor and a Ca(2+)-dependent priming catalyst effectively explains Ca(2+)-dependent properties of neurosecretion.Molecular origins of synaptotagmin 1 activities on vesicle docking and fusion pore opening.Re-visiting the trans insertion model for complexin clamping.Genome-wide association study revealed genomic regions related to white/red earlobe color trait in the Rhode Island Red chickensThree steps forward, two steps back: mechanistic insights into the assembly and disassembly of the SNARE complex.Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion.Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis.Accelerating SNARE-Mediated Membrane Fusion by DNA-Lipid Tethers.Nanodisc-cell fusion: control of fusion pore nucleation and lifetimes by SNARE protein transmembrane domains.Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complexComplexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic stateComparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins.Point mutation in syntaxin-1A causes abnormal vesicle recycling, behaviors, and short term plasticity.Conformational dynamics of calcium-triggered activation of fusion by synaptotagmin.Complexin synchronizes primed vesicle exocytosis and regulates fusion pore dynamics.A half-zippered SNARE complex represents a functional intermediate in membrane fusion.The impact of bacterial infection on mast cell degranulation.The blockade of the neurotransmitter release apparatus by botulinum neurotoxins.The Multifaceted Role of SNARE Proteins in Membrane Fusion.
P2860
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P2860
A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
A conformational switch in com ...... min to trigger synaptic fusion
@ast
A conformational switch in com ...... min to trigger synaptic fusion
@en
A conformational switch in com ...... min to trigger synaptic fusion
@nl
type
label
A conformational switch in com ...... min to trigger synaptic fusion
@ast
A conformational switch in com ...... min to trigger synaptic fusion
@en
A conformational switch in com ...... min to trigger synaptic fusion
@nl
prefLabel
A conformational switch in com ...... min to trigger synaptic fusion
@ast
A conformational switch in com ...... min to trigger synaptic fusion
@en
A conformational switch in com ...... min to trigger synaptic fusion
@nl
P2093
P2860
P3181
P356
P1476
A conformational switch in com ...... min to trigger synaptic fusion
@en
P2093
Claudio G Giraudo
Daniel Kümmel
Daniel T Radoff
James E Rothman
Jeff Coleman
Karin M Reinisch
Lavan Khandan
Stephanie Wood Baguley
P2860
P2888
P304
P3181
P356
10.1038/NSMB.2103
P407
P577
2011-07-24T00:00:00Z