Determinants of HIV-1 coreceptor function on CC chemokine receptor 3. Importance of both extracellular and transmembrane/cytoplasmic regions
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CCR5 HIV-1 coreceptor activity. Role of cooperativity between residues in N-terminal extracellular and intracellular domainsPathogenesis of primary R5 human immunodeficiency virus type 1 clones in SCID-hu miceA small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry.Small molecule receptor agonists and antagonists of CCR3 provide insight into mechanisms of chemokine receptor activation.Will multiple coreceptors need to be targeted by inhibitors of human immunodeficiency virus type 1 entry?V3 recombinants indicate a central role for CCR5 as a coreceptor in tissue infection by human immunodeficiency virus type 1.Patterns of CCR5, CXCR4, and CCR3 usage by envelope glycoproteins from human immunodeficiency virus type 1 primary isolates.Use of coreceptors other than CCR5 by non-syncytium-inducing adult and pediatric isolates of human immunodeficiency virus type 1 is rare in vitroExpression and use of human immunodeficiency virus type 1 coreceptors by human alveolar macrophagesPersistent CCR5 utilization and enhanced macrophage tropism by primary blood human immunodeficiency virus type 1 isolates from advanced stages of disease and comparison to tissue-derived isolatesPositive and negative aspects of the human immunodeficiency virus protease: development of inhibitors versus its role in AIDS pathogenesisIdentification of a subset of human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus strains able to exploit an alternative coreceptor on untransformed human brain and lymphoid cells.CCR5 coreceptor utilization involves a highly conserved arginine residue of HIV type 1 gp120.The leukotriene B4 receptor functions as a novel type of coreceptor mediating entry of primary HIV-1 isolates into CD4-positive cells.A new monoclonal antibody, mAb 4A12, identifies a role for the glycosaminoglycan (GAG) binding domain of RANTES in the antiviral effect against HIV-1 and intracellular Ca2+ signaling.Virus entry via the alternative coreceptors CCR3 and FPRL1 differs by human immunodeficiency virus type 1 subtype.Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach.Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity.Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein.Reduced cell surface expression of CCR5 in CCR5Delta 32 heterozygotes is mediated by gene dosage, rather than by receptor sequestration.Determinants for sensitivity of human immunodeficiency virus coreceptor CXCR4 to the bicyclam AMD3100The identification, characterization, and distribution of guinea pig CCR4 and epitope mapping of a blocking antibody.Pseudotypes of vesicular stomatitis virus-bearing envelope antigens of certain HIV-1 strains permissively infect human syncytiotrophoblasts cultured in vitro: implications for in vivo infection of syncytiotrophoblasts by cell-free HIV-1.Naturally occurring CCR5 extracellular and transmembrane domain variants affect HIV-1 Co-receptor and ligand binding function.Human herpesvirus 6 variant a infects human term syncytiotrophoblasts in vitro and induces replication of human immunodeficiency virus type 1 in dually infected cells.A membrane-proximal basic domain and cysteine cluster in the C-terminal tail of CCR5 constitute a bipartite motif critical for cell surface expression.The N-terminal extracellular segments of the chemokine receptors CCR1 and CCR3 are determinants for MIP-1alpha and eotaxin binding, respectively, but a second domain is essential for efficient receptor activation.CXCR7/ACKR3-targeting ligands interfere with X7 HIV-1 and HIV-2 entry and replication in human host cells.
P2860
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P2860
Determinants of HIV-1 coreceptor function on CC chemokine receptor 3. Importance of both extracellular and transmembrane/cytoplasmic regions
description
1997 nî lūn-bûn
@nan
1997 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Determinants of HIV-1 corecept ...... nsmembrane/cytoplasmic regions
@ast
Determinants of HIV-1 corecept ...... nsmembrane/cytoplasmic regions
@en
Determinants of HIV-1 corecept ...... nsmembrane/cytoplasmic regions
@nl
type
label
Determinants of HIV-1 corecept ...... nsmembrane/cytoplasmic regions
@ast
Determinants of HIV-1 corecept ...... nsmembrane/cytoplasmic regions
@en
Determinants of HIV-1 corecept ...... nsmembrane/cytoplasmic regions
@nl
prefLabel
Determinants of HIV-1 corecept ...... nsmembrane/cytoplasmic regions
@ast
Determinants of HIV-1 corecept ...... nsmembrane/cytoplasmic regions
@en
Determinants of HIV-1 corecept ...... nsmembrane/cytoplasmic regions
@nl
P2093
P2860
P356
P1476
Determinants of HIV-1 corecept ...... nsmembrane/cytoplasmic regions
@en
P2093
E A Berger
G Alkhatib
P M Murphy
P2860
P304
P356
10.1074/JBC.272.33.20420
P407
P577
1997-08-15T00:00:00Z