Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity.
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The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activationAtomic-level mapping of antibody epitopes on a GPCRThe tetrahydroisoquinoline derivative SB269,652 is an allosteric antagonist at dopamine D3 and D2 receptorsBinding modes of CCR5-targetting HIV entry inhibitors: partial and full antagonistsThe human olfactory receptor repertoireNormal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domainsToward the discovery of vaccine adjuvants: coupling in silico screening and in vitro analysis of antagonist binding to human and mouse CCR4 receptorsStructure-function analysis of the extracellular domains of the Duffy antigen/receptor for chemokines: characterization of antibody and chemokine binding sitesMultiple active states and oligomerization of CCR5 revealed by functional properties of monoclonal antibodies.Identification of a linear peptide recognized by monoclonal antibody 2D7 capable of generating CCR5-specific antibodies with human immunodeficiency virus-neutralizing activity.The bovine chemokine receptors and their mRNA abundance in mononuclear phagocytes.N-linked glycosylation of CXCR4 masks coreceptor function for CCR5-dependent human immunodeficiency virus type 1 isolates.Cooperation of multiple CCR5 coreceptors is required for infections by human immunodeficiency virus type 1Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Structure modeling of the chemokine receptor CCR5: implications for ligand binding and selectivity.Third extracellular loop (EC3)-N terminus interaction is important for seven-transmembrane domain receptor function: implications for an activation microswitch region.Identification of conserved and variable structures in the human immunodeficiency virus gp120 glycoprotein of importance for CXCR4 bindingVariants of CCR5, which are permissive for HIV-1 infection, show distinct functional responses to CCL3, CCL4 and CCL5.Structural and molecular interactions of CCR5 inhibitors with CCR5.HIV-1 infection through the CCR5 receptor is blocked by receptor dimerization.Persistent resistance to HIV-1 infection in CD4 T cells from exposed uninfected Vietnamese individuals is mediated by entry and post-entry blocks.Molecular cloning and characterization of the allatotropin precursor and receptor in the desert locust, Schistocerca gregaria.Allosteric model of maraviroc binding to CC chemokine receptor 5 (CCR5).Functional Mimetics of the HIV-1 CCR5 Co-Receptor Displayed on the Surface of Magnetic Liposomes.Peptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1.CCR5 susceptibility to ligand-mediated down-modulation differs between human T lymphocytes and myeloid cells.Peptide, peptidomimetic and small-molecule drug discovery targeting HIV-1 host-cell attachment and entry through gp120, gp41, CCR5 and CXCR4.Structural basis of chemokine receptor function--a model for binding affinity and ligand selectivitySoluble mimics of a chemokine receptor: chemokine binding by receptor elements juxtaposed on a soluble scaffoldThe sense of smell: molecular basis of odorant recognition.Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance.Structure-function analysis of human immunodeficiency virus type 1 gp120 amino acid mutations associated with resistance to the CCR5 coreceptor antagonist vicriviroc.C-C chemokine receptor type five (CCR5): An emerging target for the control of HIV infection.The membrane proximal region of the cannabinoid receptor CB1 N-terminus can allosterically modulate ligand affinity.Antibody epitopes on g protein-coupled receptors mapped with genetically encoded photoactivatable cross-linkers.G protein coupled receptors as allosteric proteins and the role of allosteric modulators.Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule BindingPalmitoylation of CCR5 is critical for receptor trafficking and efficient activation of intracellular signaling pathways.Activation of CCR5 by chemokines involves an aromatic cluster between transmembrane helices 2 and 3.Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation.
P2860
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P2860
Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Extracellular cysteines of CCR ...... for HIV-1 coreceptor activity.
@en
type
label
Extracellular cysteines of CCR ...... for HIV-1 coreceptor activity.
@en
prefLabel
Extracellular cysteines of CCR ...... for HIV-1 coreceptor activity.
@en
P2093
P2860
P921
P356
P1476
Extracellular cysteines of CCR ...... for HIV-1 coreceptor activity.
@en
P2093
Blanpain C
Govaerts C
Migeotte I
Parmentier M
P2860
P304
18902-18908
P356
10.1074/JBC.274.27.18902
P407
P50
P577
1999-07-01T00:00:00Z