Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds
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A conformational change in the peripheral anionic site of Torpedo californica acetylcholinesterase induced by a bis-imidazolium oximeButyrylcholinesterase for protection from organophosphorus poisons: catalytic complexities and hysteretic behavior(E)-4-Nitro-benzaldehyde oxime(E)-3,5-Dimeth-oxy-benzaldehyde oximeStudy of para-Quinone Methide Precursors toward the Realkylation of Aged Acetylcholinesterase.Detoxification of Organophosphate Poisoning Using Nanoparticle BioscavengersKinetic assessment of N-methyl-2-methoxypyridinium species as phosphonate anion methylating agentsAssessment of serum cholinesterase in rural punjabi sprayers exposed to a mixture of pesticides.Relationships between the antidotal efficacy and structure, PK/PD parameters and bio-relevant molecular descriptors of AChE reactivating oximes: inclusion and integration to biopharmaceutical classification systems.Curious Cases of the Enzymes.Organophosphate-Hydrolyzing Enzymes as First-Line of Defence Against Nerve Agent-Poisoning: Perspectives and the Road Ahead.Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Essential Lessons in a Potential Sarin Attack Disaster Plan for a Resource-Constrained Environment.Recent advances in the treatment of organophosphorous poisonings.Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats.In vitro reactivation kinetics of paraoxon- and DFP-inhibited electric eel AChE using mono- and bis-pyridinium oximes.A comparison of the reactivating and therapeutic efficacy of chosen combinations of oximes with individual oximes against VX in rats and mice.A comparison of the ability of newly-developed bispyridinium oxime K203 and currently available oximes (trimedoxime, obidoxime, HI-6) to counteract the acute neurotoxicity of soman in rats.The significance of the measurement of serum xanthine oxidase and oxidation markers in patients with acute organophosphorus pesticide poisoning.The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of soman poisoning in rats and mice.Unbinding free energy of acetylcholinesterase bound oxime drugs along the gorge pathway from metadynamics-umbrella sampling investigation.Oxime-mediated in vitro reactivation kinetic analysis of organophosphates-inhibited human and electric eel acetylcholinesterase.Changes of rat plasma total low molecular weight antioxidant level after tabun exposure and consequent treatment by acetylcholinesterase reactivators.Nanoparticle-based immunochromatographic test strip with fluorescent detector for quantification of phosphorylated acetylcholinesterase: an exposure biomarker of organophosphorus agents.The Evaluation of the Reactivating and Neuroprotective Efficacy of Two Newly Prepared Bispyridinium Oximes (K305, K307) in Tabun-Poisoned Rats-A Comparison with Trimedoxime and the Oxime K203.A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice.The evaluation of the reactivating and therapeutic efficacy of three novel bispyridinium oximes (K454, K456, K458) in comparison with the oxime K203 and trimedoxime in tabun-poisoned rats and mice.A comparison of the reactivating and therapeutic efficacy of two newly developed oximes (k727 and k733) with oxime k203 and trimedoxime in tabun-poisoned rats and mice.Evaluation of acetylcholine, seizure activity and neuropathology following high-dose nerve agent exposure and delayed neuroprotective treatment drugs in freely moving rats.The evaluation of the reactivating and therapeutic efficacy of two novel oximes (K361 and K378) in comparison with the oxime K203 and trimedoxime in tabun-poisoned rats and mice.Combined approach to demonstrate acetylcholinesterase activity changes in the rat brain following tabun intoxication and its treatment.Evaluation of the Influence of Three Newly Developed Bispyridinium Anti-nicotinic Compounds (MB408, MB442, MB444) on the Efficacy of Antidotal Treatment of Nerve Agent Poisoning in Mice.Why is Aged Acetylcholinesterase So Difficult to Reactivate?Evaluation of the benefit of the bispyridinium compound MB327 for the antidotal treatment of nerve agent-poisoned mice.Assessment of DNA-binding affinity of cholinesterase reactivators and electrophoretic determination of their effect on topoisomerase I and II activity.Stripping voltammetric determination of pyridine-2-aldoxime methochloride at the iron(iii) doped zeolite modified glassy carbon electrode
P2860
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P2860
Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds
description
2009 nî lūn-bûn
@nan
2009 թուականին հրատարակուած գիտական յօդուած
@hyw
2009 թվականին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Pyridinium oximes as cholinest ...... ith organophosphorus compounds
@ast
Pyridinium oximes as cholinest ...... ith organophosphorus compounds
@en
Pyridinium oximes as cholinest ...... ith organophosphorus compounds
@nl
type
label
Pyridinium oximes as cholinest ...... ith organophosphorus compounds
@ast
Pyridinium oximes as cholinest ...... ith organophosphorus compounds
@en
Pyridinium oximes as cholinest ...... ith organophosphorus compounds
@nl
prefLabel
Pyridinium oximes as cholinest ...... ith organophosphorus compounds
@ast
Pyridinium oximes as cholinest ...... ith organophosphorus compounds
@en
Pyridinium oximes as cholinest ...... ith organophosphorus compounds
@nl
P1476
Pyridinium oximes as cholinest ...... ith organophosphorus compounds
@en
P2093
Milan Jokanović
Milica Prostran
P304
P356
10.2174/092986709788612729
P407
P577
2009-01-01T00:00:00Z