Relationships between the antidotal efficacy and structure, PK/PD parameters and bio-relevant molecular descriptors of AChE reactivating oximes: inclusion and integration to biopharmaceutical classification systems.

Relationships between the antidotal efficacy and structure, PK/PD parameters and bio-relevant molecular descriptors of AChE reactivating oximes: inclusion and integration to biopharmaceutical classification systems.

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Translation of in vitro to in vivo pyridinium oxime potential in tabun poisoning.

P2860

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P2860

Relationships between the antidotal efficacy and structure, PK/PD parameters and bio-relevant molecular descriptors of AChE reactivating oximes: inclusion and integration to biopharmaceutical classification systems.

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http://www.wikidata.org/entity/Q38265360

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2014 nî lūn-bûn

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2014年の論文

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2014年学术文章

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Relationships between the anti ...... utical classification systems.

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Relationships between the anti ...... utical classification systems.

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Relationships between the anti ...... utical classification systems.

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Relationships between the anti ...... utical classification systems.

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Andrei Medvedovici

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Flavian Ştefan Rădulescu

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Victor Voicu

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P2860

Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability

Cerebral acetylcholine and choline contents and turnover following low-dose acetylcholinesterase inhibitors treatment in rats

A physiologically based pharmacokinetic model for the oxime TMB-4: simulation of rodent and human data.

Evaluation of medical countermeasures against organophosphorus compounds: the value of experimental data and computer simulations.

Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents.

BDDCS applied to over 900 drugs.

Structural requirements for effective oximes--evaluation of kinetic in vitro data with phosphylated human AChE and structurally different oximes.

Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system.

Differences between organophosphorus insecticides in human self-poisoning: a prospective cohort study.

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95-109

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scholarly article

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10.1517/17425255.2015.980813

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English

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2014-11-06T00:00:00Z

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25373357

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Relationships between the antidotal efficacy and structure, PK/PD parameters and bio-relevant molecular descriptors of AChE reactivating oximes: inclusion and integration to biopharmaceutical classification systems.

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P2860

P2860

Relationships between the antidotal efficacy and structure, PK/PD parameters and bio-relevant molecular descriptors of AChE reactivating oximes: inclusion and integration to biopharmaceutical classification systems.

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