Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1 - Wikidata - awgldk - TriplyDB

Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1

Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1

http://www.wikidata.org/entity/Q28248333

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Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission An emerging role for TOR signaling in mammalian tissue and stem cell physiology Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1 Recent Advances in Understanding Amino Acid Sensing Mechanisms that Regulate mTORC1 PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome MondoA-Mlx transcriptional activity is limited by mTOR-MondoA interaction Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908.cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4.Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR.Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation.mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action Mammalian Target of Rapamycin Inhibitors Resistance Mechanisms in Clear Cell Renal Cell Carcinoma.Rheb and Rags come together at the lysosome to activate mTORC1.The TSC1-TSC2 complex consists of multiple TSC1 and TSC2 subunits.Stoichiometry and assembly of mTOR complexes revealed by single-molecule pulldown.Activating mutations of TOR (target of rapamycin).Mammalian target of rapamycin complex I (mTORC1) activity in ras homologue enriched in brain (Rheb)-deficient mouse embryonic fibroblasts The role of hypothalamic mTORC1 signaling in insulin regulation of food intake, body weight, and sympathetic nerve activity in male mice.The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells Keratin 17 Is Induced in Oral Cancer and Facilitates Tumor Growth Target of Rapamycin Is a Key Player for Auxin Signaling Transduction in Arabidopsis.Organ size control by Hippo and TOR pathways.Hypothalamic mTORC1 signaling controls sympathetic nerve activity and arterial pressure and mediates leptin effects Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3.Stimulation of muscle protein synthesis by somatotropin in pigs is independent of the somatotropin-induced increase in circulating insulin.Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1.Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth.The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer: a retrospective study including patients from the randomised Stockholm tamoxifen trials S6K2: The Neglected S6 Kinase Family Member.Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation.Activation of mTOR: a culprit of Alzheimer's disease?Effects of Metformin and a Mammalian Target of Rapamycin (mTOR) ATP-Competitive Inhibitor on Targeted Metabolomics in Pancreatic Cancer Cell Line.Mammalian target of rapamycin (mTOR): a central regulator of male fertility?Different effects of histone deacetylase inhibitors nicotinamide and trichostatin A (TSA) in C17.2 neural stem cells.Structure of the human mTOR complex I and its implications for rapamycin inhibition.MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy.

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P2860

Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1

http://www.wikidata.org/entity/Q28248333

description

2006 nî lūn-bûn

@nan

2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի օգոստոսին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Activation of mammalian target ...... ding to dimeric mTOR complex 1

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Activation of mammalian target ...... ding to dimeric mTOR complex 1

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Activation of mammalian target ...... ding to dimeric mTOR complex 1

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type

label

Activation of mammalian target ...... ding to dimeric mTOR complex 1

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Activation of mammalian target ...... ding to dimeric mTOR complex 1

@en

Activation of mammalian target ...... ding to dimeric mTOR complex 1

@nl

prefLabel

Activation of mammalian target ...... ding to dimeric mTOR complex 1

@ast

Activation of mammalian target ...... ding to dimeric mTOR complex 1

@en

Activation of mammalian target ...... ding to dimeric mTOR complex 1

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P1433

Journal of Biological Chemistry

P1476

Activation of mammalian target ...... ding to dimeric mTOR complex 1

@en

P2093

Christopher J Rhodes

http://www.w3.org/2001/XMLSchema#string

John C Lawrence

http://www.w3.org/2001/XMLSchema#string

Lifu Wang

http://www.w3.org/2001/XMLSchema#string

P2860

Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin.

A simplified system for generating recombinant adenoviruses

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E

P304

24293-303

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scholarly article

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652289

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P356

10.1074/JBC.M603566200

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P433

34

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P478

281

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P577

2006-08-25T00:00:00Z

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P698

16798736

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P921