A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14)
about
The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genesFusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocationAbrogation of the G2 cell cycle checkpoint associated with overexpression of HSIX1: a possible mechanism of breast carcinogenesisG1/S transcriptional networks modulated by the HOX11/TLX1 oncogene of T-cell acute lymphoblastic leukemiaFormation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3A novel pathogenesis of megacolon in Ncx/Hox11L.1 deficient miceProper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1Thymic overexpression of Ttg-1 in transgenic mice results in T-cell acute lymphoblastic leukemia/lymphomaDevelopment expression of Hox11 and specification of splenic cell fate.The T-cell oncogenic protein HOX11 activates Aldh1 expression in NIH 3T3 cells but represses its expression in mouse spleen development.Transient responses to NOTCH and TLX1/HOX11 inhibition in T-cell acute lymphoblastic leukemia/lymphomaConditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene.The optimal binding sequence of the Hox11 protein contains a predicted recognition core motif.Ectopic TLX1 expression accelerates malignancies in mice deficient in DNA-PK.Transcriptional activation by TAL1 and FUS-CHOP proteins expressed in acute malignancies as a result of chromosomal abnormalities.Structure and expression of the human trithorax-like gene 1 involved in acute leukemias.Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch allelesCooperative interactions between HOX and PBX proteins mediated by a conserved peptide motifTLX1/HOX11-mediated disruption of primary thymocyte differentiation prior to the CD4+CD8+ double-positive stage.A model for spontaneous B-lineage lymphomas in IgHmu-HOX11 transgenic mice.The NOTCH signaling pathway: role in the pathogenesis of T-cell acute lymphoblastic leukemia and implication for therapy.TLX1 (HOX11) immortalization of embryonic stem cell-derived and primary murine hematopoietic progenitors.Induction of tolerance to immunogenic tumor antigens associated with lymphomagenesis in HOX11 transgenic mice.Hematopoietic immortalizing function of the NKL-subclass homeobox gene TLX1.Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia.The molecular basis of T cell acute lymphoblastic leukemiaOptimal activation of an endogenous gene by HOX11 requires the NH2-terminal 50 amino acidsTransformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable.Phosphorylation of HOX11/TLX1 on Threonine-247 during mitosis modulates expression of cyclin B1.
P2860
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P2860
A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14)
description
1991 nî lūn-bûn
@nan
1991 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
A novel human homeobox gene li ...... mosomal translocation t(10;14)
@ast
A novel human homeobox gene li ...... mosomal translocation t(10;14)
@en
A novel human homeobox gene li ...... mosomal translocation t(10;14)
@nl
type
label
A novel human homeobox gene li ...... mosomal translocation t(10;14)
@ast
A novel human homeobox gene li ...... mosomal translocation t(10;14)
@en
A novel human homeobox gene li ...... mosomal translocation t(10;14)
@nl
prefLabel
A novel human homeobox gene li ...... mosomal translocation t(10;14)
@ast
A novel human homeobox gene li ...... mosomal translocation t(10;14)
@en
A novel human homeobox gene li ...... mosomal translocation t(10;14)
@nl
P2093
P1433
P1476
A novel human homeobox gene li ...... mosomal translocation t(10;14)
@en
P2093
A J Carroll
J Minowada
S C Raimondi
S Kamel-Reid
P304
P407
P577
1991-12-01T00:00:00Z