Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable.
about
Prep2: cloning and expression of a new prep family memberThe AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLFThe novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativityAbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteinsHelix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cellsCritical role for a single leucine residue in leukemia induction by E2A-PBX1Immunocytochemical detection of HoxD9 and Pbx1 homeodomain protein expression in Chinese esophageal squamous cell carcinomasA conserved C-terminal domain in PBX increases DNA binding by the PBX homeodomain and is not a primary site of contact for the YPWM motif of HOXA1Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteinsMechanisms of chromosomal rearrangement in the human genomeMurine models of acute leukemia: important tools in current pediatric leukemia research.Selective repression of transcriptional activators by Pbx1 does not require the homeodomainHigh incidence of proviral integrations in the Hoxa locus in a new model of E2a-PBX1-induced B-cell leukemia.The oncoprotein E2A-Pbx1a collaborates with Hoxa9 to acutely transform primary bone marrow cellsRole for homodimerization in growth deregulation by E2a fusion proteins.Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemiaThe role of E2A-PBX1 in leukemogenesis.E2A-HLF usurps control of evolutionarily conserved survival pathways.The structure of the human ALL-1/MLL/HRX gene.Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes.HOX and non-HOX homeobox genes in leukemic hematopoiesis.Direct and indirect targets of the E2A-PBX1 leukemia-specific fusion protein.Fusion of the genes EWSR1 and PBX3 in retroperitoneal leiomyoma with t(9;22)(q33;q12).E2a/Pbx1 induces the rapid proliferation of stem cell factor-dependent murine pro-T cells that cause acute T-lymphoid or myeloid leukemias in mice.Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program.Retrovirus-Mediated Expression of E2A-PBX1 Blocks Lymphoid Fate but Permits Retention of Myeloid Potential in Early Hematopoietic Progenitors.Restricted expression of E2A protein in primary human tissues correlates with proliferation and differentiation.Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia.Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motifThe AD1 transactivation domain of E2A contains a highly conserved helix which is required for its activity in both Saccharomyces cerevisiae and mammalian cells.Pbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the Hox locus.The Hox cooperativity motif of the chimeric oncoprotein E2a-Pbx1 is necessary and sufficient for oncogenesis.Detection of E2A-PBX1 fusion transcripts in human non-small-cell lung cancerMechanisms of transcription factor deregulation in lymphoid cell transformation.Differential involvement of E2A-corepressor interactions in distinct leukemogenic pathways.Genetically engineered mouse models of human B-cell precursor leukemias.Cellular transformation of NIH3T3 fibroblasts by CIZ/NMP4 fusions.Mechanisms of human lymphoid chromosomal translocations.The oncogenic potential of the Pax3-FKHR fusion protein requires the Pax3 homeodomain recognition helix but not the Pax3 paired-box DNA binding domain.
P2860
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P2860
Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Transformation properties of t ...... x1 homeodomain is dispensable.
@en
type
label
Transformation properties of t ...... x1 homeodomain is dispensable.
@en
prefLabel
Transformation properties of t ...... x1 homeodomain is dispensable.
@en
P2093
P2860
P356
P1476
Transformation properties of t ...... x1 homeodomain is dispensable.
@en
P2093
P2860
P304
P356
10.1128/MCB.14.12.8304
P407
P577
1994-12-01T00:00:00Z