Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding
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Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC moleculeIdentification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex moleculesHuman immunodeficiency virus type 1 envelope glycoprotein gp120 produces immune defects in CD4+ T lymphocytes by inhibiting interleukin 2 mRNACharacterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigensCD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infectionAnti-HIV agents targeting the interaction of gp120 with the cellular CD4 receptor.A simple detection method for low-affinity membrane protein interactions by baculoviral display.Human immunodeficiency virus infection is efficiently mediated by a glycolipid-anchored form of CD4.Novel peptides based on HIV-1 gp120 sequence with homology to chemokines inhibit HIV infection in cell culture.Anti-HIV and anti-anti-MHC antibodies in alloimmune and autoimmune mice.Oligomerization of CD4 is required for stable binding to class II major histocompatibility complex proteins but not for interaction with human immunodeficiency virus gp120.Role of CD4 molecule in the induction of interleukin 2 and interleukin 2 receptor in class II major histocompatibility complex-restricted antigen-specific T helper clones. T cell receptor/CD3 complex transmits CD4-dependent and CD4-independent signaModulation of CD4 T cell function by soluble MHC II-peptide chimeras.Human immunodeficiency virus type 1 gp120 mimics a hidden monomorphic epitope borne by class I major histocompatibility complex heavy chains.Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulationCrystal structure of an HIV-binding recombinant fragment of human CD4.The role of charge and multiple faces of the CD8 alpha/alpha homodimer in binding to major histocompatibility complex class I molecules: support for a bivalent model.CD4 on the road to coreceptor status.Virus receptors: implications for pathogenesis and the design of antiviral agents.Functional epitope analysis of the human CD4 molecule: antibodies that inhibit human immunodeficiency virus type 1 gene expression bind to the immunoglobulin CDR3-like region of CD4RANTES and MCP-3 inhibit the replication of T-cell-tropic human immunodeficiency virus type 1 strains (SF-2, MN, and HE).A computer screening approach to immunoglobulin superfamily structures and interactions: discovery of small non-peptidic CD4 inhibitors as novel immunotherapeuticsInterferon alpha and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS.Mouse hepatitis virus strain A59 and blocking antireceptor monoclonal antibody bind to the N-terminal domain of cellular receptor.Major histocompatibility complex independent T cell receptor-antigen interaction: functional analysis using fluorescein derivatives.Mutations in CD8 that affect interactions with HLA class I and monoclonal anti-CD8 antibodies.CTLA-4 is a second receptor for the B cell activation antigen B7CD8 surface levels alter the fate of alpha/beta T cell receptor-expressing thymocytes in transgenic mice.The human immunodeficiency virus gp120 binding site on CD4: delineation by quantitative equilibrium and kinetic binding studies of mutants in conjunction with a high-resolution CD4 atomic structure.Xenogeneic proliferation and lymphokine production are dependent on CD4+ helper T cells and self antigen-presenting cells in the mouse.Mapping of the Epstein-Barr virus and C3dg binding sites to a common domain on complement receptor type 2.Equivalence of human and mouse CD4 in enhancing antigen responses by a mouse class II-restricted T cell hybridoma.CD4-mediated enhancement or inhibition of T cell activation does not require the CD4:p56lck associationInvolvement of both major histocompatibility complex class II alpha and beta chains in CD4 function indicates a role for ordered oligomerization in T cell activationThymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage.Molecular requirements for T cell recognition by a major histocompatibility complex class II-restricted T cell receptor: the involvement of the fourth hypervariable loop of the Valpha domain.Identification of CD4 and major histocompatibility complex functional peptide sites and their homology with oligopeptides from human immunodeficiency virus type 1 glycoprotein gp120: role in AIDS pathogenesisDelineation of an extended surface contact area on human CD4 involved in class II major histocompatibility complex bindingThe human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection.Mechanism for the T4 lymphopenia of AIDS.
P2860
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P2860
Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding
description
1989 nî lūn-bûn
@nan
1989 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding
@ast
Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding
@en
Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding
@nl
type
label
Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding
@ast
Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding
@en
Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding
@nl
prefLabel
Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding
@ast
Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding
@en
Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding
@nl
P2093
P356
P1433
P1476
Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding
@en
P2093
P2888
P304
P356
10.1038/339548A0
P407
P577
1989-06-15T00:00:00Z
P6179
1027932766