about
Fragment-Based Screen against HIV ProteaseColloid formation by drugs in simulated intestinal fluid.Screening library evolution through automation of solution preparation.Advances in improving the quality and flexibility of compound management.Integration of small-molecule discovery in academic biomedical researchIdentification of Small Molecule Inhibitors of Clostridium perfringens ε-Toxin Cytotoxicity Using a Cell-Based High-Throughput ScreenA Method for Identifying Small-Molecule Aggregators Using Photonic Crystal Biosensor Microplates.Fragment screening of infectious disease targets in a structural genomics environmentPhysics-based scoring of protein-ligand interactions: explicit polarizability, quantum mechanics and free energies.Hierarchical virtual screening for the discovery of new molecular scaffolds in antibacterial hit identificationThe essential roles of chemistry in high-throughput screening triageDevelopment and experimental test of support vector machines virtual screening method for searching Src inhibitors from large compound libraries.Phenylalanine hydroxylase misfolding and pharmacological chaperones.Evolutions in fragment-based drug design: the deconstruction-reconstruction approachSaturation transfer difference NMR for fragment screening.Identification of novel potential antibiotics against Staphylococcus using structure-based drug screening targeting dihydrofolate reductaseIdentification of novel inhibitors of human Chk1 using pharmacophore-based virtual screening and their evaluation as potential anti-cancer agents.Emergence of Chinese drug discovery research: impact of hit and lead identification.Pharmaceutical research in the Kingdom of Saudi Arabia: A scientometric analysis during 2001-2010.Rapid Discovery of Functional Small Molecule Ligands against Proteomic Targets through Library-Against-Library Screening.Optimizing Dvl PDZ domain inhibitor by exploring chemical space.Promiscuous aggregate-based inhibitors promote enzyme unfolding.CVDHD: a cardiovascular disease herbal database for drug discovery and network pharmacology.Virtual ligand screening combined with NMR to identify Dvl PDZ domain inhibitors targeting the Wnt signaling.Label-free screening assays: a strategy for finding better drug candidates.High-throughput and in silico screenings in drug discovery.In silico tools used for compound selection during target-based drug discovery and development.The cytotoxic and proapoptotic activities of hypnophilin are associated with calcium signaling in UACC-62 cells.A Crowd-Based Process and Tool for HTS Hit Triage.Integration of distributed computing into the drug discovery process.Ligand efficiency indices for effective drug discovery.Efficient screening of marine extracts for protease inhibitors by combining FRET based activity assays and surface plasmon resonance spectroscopy based binding assays.Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors.Hit series selection in noisy HTS data: clustering techniques, statistical tests and data visualisations.HTS explorer.Design, Synthesis and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel DPP-4 Inhibitors.Determination of antibiotic EC50 using a zero-flow microfluidic chip based growth phenotype assay.Opportunities and obstacles for deep learning in biology and medicine.Rational Design of Highly Potent and Slow-Binding Cytochrome bc1 Inhibitor as Fungicide by Computational Substitution Optimization.
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
name
Hit discovery and hit-to-lead approaches
@ast
Hit discovery and hit-to-lead approaches
@en
Hit discovery and hit-to-lead approaches
@nl
type
label
Hit discovery and hit-to-lead approaches
@ast
Hit discovery and hit-to-lead approaches
@en
Hit discovery and hit-to-lead approaches
@nl
prefLabel
Hit discovery and hit-to-lead approaches
@ast
Hit discovery and hit-to-lead approaches
@en
Hit discovery and hit-to-lead approaches
@nl
P3181
P1433
P1476
Hit discovery and hit-to-lead approaches
@en
P2093
Gergely M Makara
György M Keseru
P3181
P356
10.1016/J.DRUDIS.2006.06.016
P407
P577
2006-08-01T00:00:00Z