The essential roles of chemistry in high-throughput screening triage
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A Role for Fragment-Based Drug Design in Developing Novel Lead Compounds for Central Nervous System TargetsFluorescence anisotropy (polarization): from drug screening to precision medicine.Histone-modifying enzymes, histone modifications and histone chaperones in nucleosome assembly: Lessons learned from Rtt109 histone acetyltransferasesPrivileged Structures Revisited.Epigenetic assays for chemical biology and drug discovery.The Essential Medicinal Chemistry of CurcuminData-driven approaches used for compound library design, hit triage and bioactivity modeling in high-throughput screening.PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS.Mitigating risk in academic preclinical drug discovery.Three-dimensional structures in the design of therapeutics targeting parasitic protozoa: reflections on the past, present and future.Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR.Non-stoichiometric inhibition in integrated lead finding - a literature review.Pharmacological Chaperoning: A Potential Treatment for PMM2-CDG.Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivoHow to Triage PAINS-Full ResearchStable Colloidal Drug Aggregates Catch and Release Active Enzymes.Modern approaches to accelerate discovery of new antischistosomal drugs.The importance of triaging in determining the quality of output from high-throughput screening.Highlights from SelectBio 2015: Academic Drug Discovery Conference, Cambridge, UK, 19-20 May 2015.Dissecting the Contributions of Cooperating Gene Mutations to Cancer Phenotypes and Drug Responses with Patient-Derived iPSCs.Donated chemical probes for open science.Establishment of a high-throughput detection system for DNA demethylating agents.Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses
P2860
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P2860
The essential roles of chemistry in high-throughput screening triage
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2014 nî lūn-bûn
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2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած
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2014 թվականի հուլիսին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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The essential roles of chemistry in high-throughput screening triage
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The essential roles of chemistry in high-throughput screening triage
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The essential roles of chemistry in high-throughput screening triage
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The essential roles of chemistry in high-throughput screening triage
@ast
The essential roles of chemistry in high-throughput screening triage
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The essential roles of chemistry in high-throughput screening triage
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The essential roles of chemistry in high-throughput screening triage
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The essential roles of chemistry in high-throughput screening triage
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The essential roles of chemistry in high-throughput screening triage
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P2860
P356
P1476
The essential roles of chemistry in high-throughput screening triage
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P2093
Jayme L Dahlin
P2860
P304
P356
10.4155/FMC.14.60
P577
2014-07-01T00:00:00Z