The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation
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Atypical IκB proteins - nuclear modulators of NF-κB signalingRegulation of IkappaBalpha function and NF-kappaB signaling: AEBP1 is a novel proinflammatory mediator in macrophagesIdentification of the receptor component of the IkappaBalpha-ubiquitin ligaseIdentification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosisThe kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathwayThe interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.Functional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirementsAnalysis of domains in the IKKalpha and IKKbeta proteins that regulate their kinase activityA phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cellsTTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activationTransactivation of naturally occurring HIV-1 long terminal repeats by the JNK signaling pathway. The most frequent naturally occurring length polymorphism sequence introduces a novel binding site for AP-1 factorsThe apoptotic signaling pathway activated by Toll-like receptor-2Inhibition of SRC tyrosine kinases suppresses activation of nuclear factor-kappa B, and serine and tyrosine phosphorylation of Ikappa B-alpha in lipopolysaccharide-stimulated RAW 264.7 macrophagesCIKS, a connection to Ikappa B kinase and stress-activated protein kinaseIkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in the cytoplasm through interaction with a novel partner, RasGAP SH3-binding protein 2vCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgammaProteinase-activated receptor-2-mediated activation of stress-activated protein kinases and inhibitory kappa B kinases in NCTC 2544 keratinocytesCSN3 interacts with IKKgamma and inhibits TNF- but not IL-1-induced NF-kappaB activationHTLV-1 Tax-associated hTid-1, a human DnaJ protein, is a repressor of Ikappa B kinase beta subunitInterleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinaseRegulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase.Fas-associated factor-1 inhibits nuclear factor-kappaB (NF-kappaB) activity by interfering with nuclear translocation of the RelA (p65) subunit of NF-kappaBThe inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosisSIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanismsThe gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytesDistinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cellsA20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells.Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathwayInterleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosolIdentification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANKToll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-betaInhibition of IkappaB kinase by vaccinia virus virulence factor B14The IkappaB kinase complex: master regulator of NF-kappaB signalingThe kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2ANF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176Molecular mechanism of hTid-1, the human homolog of Drosophila tumor suppressor l(2)Tid, in the regulation of NF-kappaB activity and suppression of tumor growthProtein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosisPPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation
P2860
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P2860
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation
description
1997 nî lūn-bûn
@nan
1997 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
The IkappaB kinase complex (IK ...... ation and NF-kappaB activation
@ast
The IkappaB kinase complex (IK ...... ation and NF-kappaB activation
@en
The IkappaB kinase complex (IK ...... ation and NF-kappaB activation
@nl
type
label
The IkappaB kinase complex (IK ...... ation and NF-kappaB activation
@ast
The IkappaB kinase complex (IK ...... ation and NF-kappaB activation
@en
The IkappaB kinase complex (IK ...... ation and NF-kappaB activation
@nl
prefLabel
The IkappaB kinase complex (IK ...... ation and NF-kappaB activation
@ast
The IkappaB kinase complex (IK ...... ation and NF-kappaB activation
@en
The IkappaB kinase complex (IK ...... ation and NF-kappaB activation
@nl
P2093
P3181
P1433
P1476
The IkappaB kinase complex (IK ...... ation and NF-kappaB activation
@en
P2093
P304
P3181
P356
10.1016/S0092-8674(00)80406-7
P407
P577
1997-10-17T00:00:00Z